First episode depression during the perinatal period is associated with atopic diseases and persistently increased eosinophil and basophil levels.

IF 3.2 3区医学 Q2 PSYCHIATRY

Archives of Women's Mental Health Pub Date : 2024-10-16 DOI:10.1007/s00737-024-01522-5

En-Young N Wagner, Eva Maria Pichler, Mario Müller, Andrea Eisenhut, Ana Buadze, Yanhua Xu, Erich Seifritz, Marie-Pierre F Strippoli, Enrique Castelao, Setareh Ranjbar, Jennifer Glaus, Caroline Vandeleur, Martin Preisig, Roland von Känel, Vladeta Ajdacic-Gross

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引用次数: 0

Abstract

Purpose: A previous diagnosis of depression is a strong predictor for perinatal depression, apart from other mental disorders, stress, and atopies. It is less clear which factors interfere if perinatal depression occurs as a first depression episode (fePND).

Methods: We examined the associations with atopies and related blood parameters using data of CoLaus|PsyCoLaus.

Results: Newly occurring depression during the perinatal period but not recurrent depression was associated with a lifetime diagnosis of allergies and asthma together with persistently increased levels of basophils and eosinophils.

Conclusion: The results imply that immune function may play a relevant role in the risk of a fePND. If confirmed and detailed, these findings could serve as the basis for designing preliminary prevention strategies by observing eosinophil and basophil levels as well as symptoms of atopic diseases before/during pregnancy.

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围产期抑郁症的首次发作与特应性疾病以及嗜酸性粒细胞和嗜碱性粒细胞水平持续升高有关。

目的：除了其他精神障碍、压力和顶点外，既往的抑郁症诊断是围产期抑郁症的有力预测因素。如果围产期抑郁症是首次抑郁发作（fePND），哪些因素会对其产生干扰，目前还不太清楚：方法：我们利用CoLaus|PsyCoLaus的数据研究了围产期抑郁症与相关血液参数的关系：结果：围产期新发抑郁症（而非复发性抑郁症）与终生诊断为过敏和哮喘以及嗜碱性粒细胞和嗜酸性粒细胞水平持续升高有关：这些结果表明，免疫功能可能在罹患 fePND 的风险中扮演着重要角色。如果这些研究结果得到证实和详细说明，则可作为设计初步预防策略的基础，在怀孕前/怀孕期间观察嗜酸性粒细胞和嗜碱性粒细胞的水平以及特应性疾病的症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Women's Mental Health 医学-精神病学

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Archives of Women’s Mental Health is the official journal of the International Association for Women''s Mental Health, Marcé Society and the North American Society for Psychosocial Obstetrics and Gynecology (NASPOG). The exchange of knowledge between psychiatrists and obstetrician-gynecologists is one of the major aims of the journal. Its international scope includes psychodynamics, social and biological aspects of all psychiatric and psychosomatic disorders in women. The editors especially welcome interdisciplinary studies, focussing on the interface between psychiatry, psychosomatics, obstetrics and gynecology. Archives of Women’s Mental Health publishes rigorously reviewed research papers, short communications, case reports, review articles, invited editorials, historical perspectives, book reviews, letters to the editor, as well as conference abstracts. Only contributions written in English will be accepted. The journal assists clinicians, teachers and researchers to incorporate knowledge of all aspects of women’s mental health into current and future clinical care and research.