The STING signaling pathways and bacterial infection.

IF 6.1 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Jiayi You, Ailing Xu, Ye Wang, Guangmin Tu, Rui Huang, Shuyan Wu
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引用次数: 0

Abstract

As antibiotic-resistant bacteria continue to emerge frequently, bacterial infections have become a significant and pressing challenge to global public health. Innate immunity triggers the activation of host responses by sensing "non-self" components through various pattern recognition receptors (PRRs), serving as the first line of antibacterial defense. Stimulator of interferon genes (STING) is a PRR that binds with cyclic dinucleotides (CDN) to exert effects against bacteria, viruses, and cancer by inducing the production of type I interferon and inflammatory cytokines, and facilitating regulated cell death. Currently, drugs targeting the STING signaling pathway are predominantly applied in the fields of modulating host immune defense against cancer and viral infections, with relatively limited application in treating bacterial infections. Given the significant immunomodulatory functions of STING in the interaction between bacteria and hosts, this review summarizes the research progress on STING signaling pathways and their roles in bacterial infection, as well as the novel functions of STING modulators, aiming to offer insights for the development of antibacterial drugs.

STING 信号通路与细菌感染
随着抗生素耐药细菌的不断频繁出现,细菌感染已成为全球公共卫生面临的一项重大而紧迫的挑战。先天性免疫通过各种模式识别受体(PRR)感知 "非自身 "成分,触发激活宿主反应,成为抗菌防御的第一道防线。干扰素基因刺激器(STING)是一种 PRR,它与环状二核苷酸(CDN)结合,通过诱导 I 型干扰素和炎性细胞因子的产生,以及促进调节性细胞死亡,发挥抗击细菌、病毒和癌症的作用。目前,针对 STING 信号通路的药物主要应用于调节宿主对癌症和病毒感染的免疫防御,在治疗细菌感染方面的应用相对有限。鉴于 STING 在细菌与宿主的相互作用中具有重要的免疫调节功能,本综述总结了 STING 信号通路的研究进展及其在细菌感染中的作用,以及 STING 调节剂的新功能,旨在为抗菌药物的开发提供启示。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Apoptosis
Apoptosis 生物-生化与分子生物学
CiteScore
9.10
自引率
4.20%
发文量
85
审稿时长
1 months
期刊介绍: Apoptosis, a monthly international peer-reviewed journal, focuses on the rapid publication of innovative investigations into programmed cell death. The journal aims to stimulate research on the mechanisms and role of apoptosis in various human diseases, such as cancer, autoimmune disease, viral infection, AIDS, cardiovascular disease, neurodegenerative disorders, osteoporosis, and aging. The Editor-In-Chief acknowledges the importance of advancing clinical therapies for apoptosis-related diseases. Apoptosis considers Original Articles, Reviews, Short Communications, Letters to the Editor, and Book Reviews for publication.
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