Correlation between cognitive impairment and body composition indicators in patients with chronic kidney disease after hemodialysis.

IF 1.7 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
American journal of translational research Pub Date : 2024-09-15 eCollection Date: 2024-01-01 DOI:10.62347/HFGL5701
Dan Yuan, Zhenxing Sun, Jingjing Zhou, Xiaoqi Wang, Zhongxin Li
{"title":"Correlation between cognitive impairment and body composition indicators in patients with chronic kidney disease after hemodialysis.","authors":"Dan Yuan, Zhenxing Sun, Jingjing Zhou, Xiaoqi Wang, Zhongxin Li","doi":"10.62347/HFGL5701","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To examine the relationship between cognitive impairment and body composition indicators in chronic kidney disease (CKD) patients post-hemodialysis.</p><p><strong>Methods: </strong>This retrospective study included 110 CKD patients admitted to Beijing Luhe Hospital, Capital Medical University between January 2019 and January 2023. General clinical data and body composition indicators were compared between patients with and without cognitive impairment. Multiple logistic regression and ROC curve analysis were used to identify influencing factors and to develop a predictive model.</p><p><strong>Results: </strong>Cognitive impairment occurred in 50% of the patients post-hemodialysis. No significant differences were found in demographics, disease duration, comorbidities, or hemodialysis duration between the groups (all P > 0.05). However, significant differences were observed in body mass index (BMI) (P < 0.001), lean body mass index (LTI) (P = 0.007), fat tissue index (FTI) (P = 0.024), and total body water (TBW) (P < 0.001). Multiple logistic regression identified TBW (OR 4.900, 95% CI 3.062-7.511, P < 0.001), the TBW/extracellular water (ECW) ratio (OR 7.244, 95% CI 5.092-8.7613, P = 0.016), and the ECW/body cell mass (BCM) ratio (OR 6.720, 95% CI 4.564-8.692, P = 0.030) as independent risk factors for cognitive impairment post-hemodialysis. ROC analysis confirmed their predictive capacity, with AUC values of 0.840, 0.840, and 0.850 respectively. A predictive model incorporating these indicators was developed, showing good calibration (Hosmer-Lemeshow test, P = 0.912) and discrimination (C-index 0.974, 95% CI 0.952-0.997).</p><p><strong>Conclusion: </strong>Total body water, the TBW/ECW ratio, and the ECW/BCM ratio are independently associated with cognitive impairment in CKD patients post-hemodialysis. Body composition analysis serves as a valuable tool for predicting cognitive impairment in this population, guiding clinicians in assessing cognitive function and planning interventions for these patients.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11470360/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of translational research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.62347/HFGL5701","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: To examine the relationship between cognitive impairment and body composition indicators in chronic kidney disease (CKD) patients post-hemodialysis.

Methods: This retrospective study included 110 CKD patients admitted to Beijing Luhe Hospital, Capital Medical University between January 2019 and January 2023. General clinical data and body composition indicators were compared between patients with and without cognitive impairment. Multiple logistic regression and ROC curve analysis were used to identify influencing factors and to develop a predictive model.

Results: Cognitive impairment occurred in 50% of the patients post-hemodialysis. No significant differences were found in demographics, disease duration, comorbidities, or hemodialysis duration between the groups (all P > 0.05). However, significant differences were observed in body mass index (BMI) (P < 0.001), lean body mass index (LTI) (P = 0.007), fat tissue index (FTI) (P = 0.024), and total body water (TBW) (P < 0.001). Multiple logistic regression identified TBW (OR 4.900, 95% CI 3.062-7.511, P < 0.001), the TBW/extracellular water (ECW) ratio (OR 7.244, 95% CI 5.092-8.7613, P = 0.016), and the ECW/body cell mass (BCM) ratio (OR 6.720, 95% CI 4.564-8.692, P = 0.030) as independent risk factors for cognitive impairment post-hemodialysis. ROC analysis confirmed their predictive capacity, with AUC values of 0.840, 0.840, and 0.850 respectively. A predictive model incorporating these indicators was developed, showing good calibration (Hosmer-Lemeshow test, P = 0.912) and discrimination (C-index 0.974, 95% CI 0.952-0.997).

Conclusion: Total body water, the TBW/ECW ratio, and the ECW/BCM ratio are independently associated with cognitive impairment in CKD patients post-hemodialysis. Body composition analysis serves as a valuable tool for predicting cognitive impairment in this population, guiding clinicians in assessing cognitive function and planning interventions for these patients.

血液透析后慢性肾病患者认知障碍与身体成分指标之间的相关性。
目的探讨血液透析后慢性肾脏病(CKD)患者认知障碍与身体成分指标之间的关系:这项回顾性研究纳入了首都医科大学附属北京潞河医院在2019年1月至2023年1月期间收治的110名CKD患者。比较了有认知障碍和无认知障碍患者的一般临床数据和身体成分指标。采用多元逻辑回归和ROC曲线分析来确定影响因素并建立预测模型:结果:50%的血液透析后患者存在认知障碍。两组患者在人口统计学、病程、合并症或血液透析持续时间方面均无明显差异(P>0.05)。然而,在体重指数(BMI)(P < 0.001)、瘦体重指数(LTI)(P = 0.007)、脂肪组织指数(FTI)(P = 0.024)和体内总水分(TBW)(P < 0.001)方面观察到明显差异。多元逻辑回归发现,TBW(OR 4.900,95% CI 3.062-7.511,P <0.001)、TBW/细胞外水(ECW)比值(OR 7.244,95% CI 5.092-8.7613,P =0.016)和ECW/体细胞质量(BCM)比值(OR 6.720,95% CI 4.564-8.692,P =0.030)是血液透析后认知功能障碍的独立风险因素。ROC 分析证实了它们的预测能力,AUC 值分别为 0.840、0.840 和 0.850。结合这些指标建立的预测模型显示出良好的校准性(Hosmer-Lemeshow 检验,P = 0.912)和区分度(C 指数 0.974,95% CI 0.952-0.997):结论:身体总水分、TBW/ECW 比值和 ECW/BCM 比值与血液透析后的慢性肾脏病患者的认知障碍有独立关联。身体成分分析是预测这类人群认知功能障碍的重要工具,可指导临床医生评估认知功能并为这些患者制定干预计划。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
American journal of translational research
American journal of translational research ONCOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
自引率
0.00%
发文量
552
期刊介绍: Information not localized
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信