Progress in application of nanomedicines for enhancing cancer sono-immunotherapy

IF 8.7 1区化学 Q1 ACOUSTICS

Ultrasonics Sonochemistry Pub Date : 2024-10-15 DOI:10.1016/j.ultsonch.2024.107105

Hongxin Zhao, Fangxue Du, Xi Xiang, Yuanjiao Tang, Ziyan Feng, Ziyao Wang, Xiao Rong, Li Qiu

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引用次数: 0

Abstract

Cancer immunotherapy has significant potential as a cancer treatment since it boosts the immune system and prevents immune escape to get rid of or fight cancers. However, its clinical applicability is still limited because of the low response rate and immune-related side effects. Recently ultrasound has been shown to alter the tumor immune microenvironment, enhance the effectiveness of other antitumor therapies, and cause tumors to become more sensitive to immunotherapy, thus providing new insights into cancer treatment. Nanomedicines are also anticipated to have a positive impact on improving the immunological effects and enhancing ultrasound effect for cancer therapy. Therefore, designing effective nanomedicines enhanced ultrasound effect for augmenting sono-immunotherapy has been a pivot on anticancer therapy. In this review, the immunological impacts of various ultrasound therapeutic modalities, ultrasound parameters, and their underlying mechanisms are discussed. Moreover, we highlight the recent progress of nanomedicines synergistically enhancing sono-immunotherapy. Finally, we put forward opportunities and challenges on sono-immunotherapy.

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应用纳米药物加强癌症超声免疫疗法的进展。

癌症免疫疗法具有治疗癌症的巨大潜力，因为它能增强免疫系统，防止免疫逃逸，从而摆脱或对抗癌症。然而，由于反应率低和与免疫相关的副作用，其临床适用性仍然有限。最近的研究表明，超声波可以改变肿瘤免疫微环境，增强其他抗肿瘤疗法的效果，并使肿瘤对免疫疗法更加敏感，从而为癌症治疗提供了新的思路。纳米药物预计还将对改善免疫效应和增强癌症治疗的超声效应产生积极影响。因此，设计有效的增强超声效应的纳米药物以提高超声免疫疗法的效果已成为抗癌治疗的关键。本综述讨论了各种超声治疗模式、超声参数及其内在机制对免疫学的影响。此外，我们还重点介绍了纳米药物协同增强超声免疫疗法的最新进展。最后，我们提出了超声免疫疗法的机遇与挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ultrasonics Sonochemistry 化学-化学综合

CiteScore

15.80

自引率

11.90%

发文量

361

审稿时长

59 days

期刊介绍： Ultrasonics Sonochemistry stands as a premier international journal dedicated to the publication of high-quality research articles primarily focusing on chemical reactions and reactors induced by ultrasonic waves, known as sonochemistry. Beyond chemical reactions, the journal also welcomes contributions related to cavitation-induced events and processing, including sonoluminescence, and the transformation of materials on chemical, physical, and biological levels. Since its inception in 1994, Ultrasonics Sonochemistry has consistently maintained a top ranking in the "Acoustics" category, reflecting its esteemed reputation in the field. The journal publishes exceptional papers covering various areas of ultrasonics and sonochemistry. Its contributions are highly regarded by both academia and industry stakeholders, demonstrating its relevance and impact in advancing research and innovation.