Anything you can do, glycans do better: deglycosylation and noncanonical ubiquitination vie to rule the proteasome.

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2024-10-16 DOI:10.1016/j.tibs.2024.10.001

Nicolas Lehrbach

引用次数: 0

Abstract

The Nrf1/Nfe2L1 transcription factor is a master regulator of proteasome biogenesis. New work by Yoshida and colleagues reveals a surprising mechanism by which ubiquitination of N-glycosylated Nrf1 controls its function.

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你能做的任何事情，聚糖都能做得更好：脱糖基化和非经典泛素化争夺蛋白酶体的统治权。

Nrf1/Nfe2L1 转录因子是蛋白酶体生物生成的主调节因子。Yoshida 及其同事的新研究揭示了 N-糖基化 Nrf1 泛素化控制其功能的惊人机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.