A novel multifunctional PEEK internal fixation plate regulated by Gentamicin/chitosan coating.

IF 5.4 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-10-12 DOI:10.1016/j.colsurfb.2024.114316

Jingfeng Sun, Jinying Li, Aiting Shan, Lijuan Wang, Jiaming Ye, Shaochuan Li, Wuyi Zhou

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引用次数: 0

Abstract

Polyetheretherketone (PEEK) has been broadly used in orthopedic implant devices. Nevertheless, the bioinert tended to cause implant loosening and bacterial infection in orthopedic and trauma surgery. In this study, a drug-laden chitosan coating (CS) was constructed and deposited on the porous surface of PEEK (CG-SPEEK) internal fixation plate for multi-functionalization. The physical characterizations of CG-SPEEK were further investigated in the morphology, hydrophilicity, surface energy, roughness, drug release and mechanical properties. CG-SPEEK exhibited excellent antibacterial capabilities in both Staphylococcus aureus and Escherichia coli compared to other groups. Besides, BMSCs cells showed better biocompatibility and certain osteogenic activity on composite coating in vitro. Furthermore, CG-SPEEK promoted bone regeneration to some extent and express certain effect against infections in vivo study. Overall, combining personalized design and modification is an innovative strategy to realized functionalization, which may have a strong potential in clinical application.

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由庆大霉素/壳聚糖涂层调节的新型多功能 PEEK 内固定板。

聚醚醚酮（PEEK）已被广泛用于骨科植入装置。然而，在骨科和创伤外科手术中，生物惰性往往会导致植入物松动和细菌感染。本研究在 PEEK（CG-SPEEK）内固定板的多孔表面上构建并沉积了含药物的壳聚糖涂层（CS），以实现多功能化。研究进一步考察了 CG-SPEEK 的形貌、亲水性、表面能、粗糙度、药物释放和机械性能。与其他组相比，CG-SPEEK 对金黄色葡萄球菌和大肠杆菌都有很好的抗菌能力。此外，BMSCs 细胞在体外对复合涂层表现出更好的生物相容性和一定的成骨活性。此外，在体内研究中，CG-SPEEK 在一定程度上促进了骨再生，并具有一定的抗感染作用。总之，将个性化设计与改性相结合是实现功能化的一种创新策略，在临床应用方面具有很大的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.