NIR-II Image-Guided Wound Healing in Hypoxic Diabetic Foot Ulcers: The Potential of Ergothioneine-Luteolin-Chitin Hydrogels.

IF 4.2 3区化学 Q2 POLYMER SCIENCE

Macromolecular Rapid Communications Pub Date : 2024-10-18 DOI:10.1002/marc.202400528

Yao Yang, Shengnan He, Wumei Wang, Yiwen Lu, Bingtao Ren, Ci Dan, Yang Ji, Rui Yu, Xinpeng Ju, Xue Qiao, Yuling Xiao, Jie Cai, Xuechuan Hong

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引用次数: 0

Abstract

Hypoxic diabetic foot ulcers (HDFUs) pose a challenging chronic condition characterized by oxidative stress damage, bacterial infection, and persistent inflammation. This study introduces a novel therapeutic approach combining ergothioneine (EGT), luteolin (LUT), and quaternized chitosan oxidized dextran (QCOD) to address these challenges and facilitate wound healing in hypoxic DFUs. In vitro, assessments have validated the biosafety, antioxidant, and antimicrobial properties of the ergothioneine-luteolin-chitin (QCOD@EGT-LUT) hydrogel. Furthermore, near-infrared II (NIR-II) fluorescence image-guided the application of QCOD@EGT-LUT hydrogel in simulated HDFUs. Mechanistically, QCOD@EGT-LUT hydrogel modulates the diabetic wound microenvironment by reducing reactive oxygen species (ROS). In vivo studies demonstrated increased expression of angiogenic factors mannose receptor (CD206) and latelet endothelial cell adhesion molecule-1 (PECAM-1/CD31), coupled with decreased inflammatory factors tumor necrosis factor-α (TNF-α) and Interleukin-6 (IL-6), thereby promoting diabetic wound healing through up-regulation of transforming growth factor β-1 (TGF-β1).

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缺氧性糖尿病足溃疡的近红外-II 图像引导伤口愈合：麦角硫因-木犀草素-柠檬素水凝胶的潜力。

缺氧性糖尿病足溃疡（HDFUs）是一种具有挑战性的慢性疾病，其特点是氧化应激损伤、细菌感染和持续炎症。本研究介绍了一种结合麦角硫因（EGT）、木犀草素（LUT）和季铵化壳聚糖氧化葡聚糖（QCOD）的新型治疗方法，以应对这些挑战并促进缺氧性糖尿病足溃疡的伤口愈合。体外评估验证了麦角硫因-木犀草素-几丁质（QCOD@EGT-LUT）水凝胶的生物安全性、抗氧化性和抗菌性。此外，近红外 II（NIR-II）荧光图像引导了 QCOD@EGT-LUT 水凝胶在模拟 HDFU 中的应用。从机理上讲，QCOD@EGT-LUT 水凝胶通过减少活性氧（ROS）调节糖尿病伤口微环境。体内研究表明，血管生成因子甘露糖受体（CD206）和小内皮细胞粘附分子-1（PECAM-1/CD31）的表达增加，同时炎症因子肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）减少，从而通过上调转化生长因子β-1（TGF-β1）促进糖尿病伤口愈合。

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来源期刊

Macromolecular Rapid Communications 工程技术-高分子科学

CiteScore

7.70

自引率

6.50%

发文量

477

审稿时长

1.4 months

期刊介绍： Macromolecular Rapid Communications publishes original research in polymer science, ranging from chemistry and physics of polymers to polymers in materials science and life sciences.