Molecular recognition of peptides and proteins by cucurbit[n]urils: systems and applications

IF 40.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Lilyanna Armstrong, Sarah L. Chang, Nia Clements, Zoheb Hirani, Lauren B. Kimberly, Keturah Odoi-Adams, Paolo Suating, Hailey F. Taylor, Sara A. Trauth and Adam R. Urbach
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引用次数: 0

Abstract

The development of methodology for attaching ligand binding sites to proteins of interest has accelerated biomedical science. Such protein tags have widespread applications as well as properties that significantly limit their utility. This review describes the mechanisms and applications of supramolecular systems comprising the synthetic receptors cucurbit[7]uril (Q7) or cucurbit[8]uril (Q8) and their polypeptide ligands. Molecular recognition of peptides and proteins occurs at sites of 1–3 amino acids with high selectivity and affinity via several distinct mechanisms, which are supported by extensive thermodynamic and structural studies in aqueous media. The commercial availability, low cost, high stability, and biocompatibility of these synthetic receptors has led to the development of myriad applications. This comprehensive review compiles the molecular recognition studies and the resulting applications with the goals of providing a valuable resource to the community and inspiring the next generation of innovation.

Abstract Image

葫芦[n]脲对肽和蛋白质的分子识别:系统和应用。
将配体结合位点附着到相关蛋白质上的方法的开发加速了生物医学科学的发展。这些蛋白质标签应用广泛,但其特性也大大限制了它们的用途。本综述介绍了由合成受体葫芦[7]脲(Q7)或葫芦[8]脲(Q8)及其多肽配体组成的超分子系统的机制和应用。肽和蛋白质的分子识别发生在 1-3 个氨基酸的位点上,通过几种不同的机制具有高选择性和亲和性,这些机制得到了水介质中大量热力学和结构研究的支持。这些合成受体具有商业可用性、低成本、高稳定性和生物相容性,因此被广泛应用于各种领域。本综述汇编了分子识别研究和由此产生的应用,旨在为社会提供有价值的资源,并激励下一代创新。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Chemical Society Reviews
Chemical Society Reviews 化学-化学综合
CiteScore
80.80
自引率
1.10%
发文量
345
审稿时长
6.0 months
期刊介绍: Chemical Society Reviews is published by: Royal Society of Chemistry. Focus: Review articles on topics of current interest in chemistry; Predecessors: Quarterly Reviews, Chemical Society (1947–1971); Current title: Since 1971; Impact factor: 60.615 (2021); Themed issues: Occasional themed issues on new and emerging areas of research in the chemical sciences
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