Electrical stimulation and conductive materials: electrophysiology-based treatment for spinal cord injury

IF 5.8 3区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

Biomaterials Science Pub Date : 2024-09-30 DOI:10.1039/D4BM00959B

Jing Guo, Jian Cao, Jiahe Wu and Jianqing Gao

{"title":"Electrical stimulation and conductive materials: electrophysiology-based treatment for spinal cord injury","authors":"Jing Guo, Jian Cao, Jiahe Wu and Jianqing Gao","doi":"10.1039/D4BM00959B","DOIUrl":null,"url":null,"abstract":"<p >Spinal cord injury is a serious disease of the central nervous system. The electrophysiological properties of the spinal cord that are essential to maintaining neurotransmission can be impaired after the injury. Therefore, electrophysiological evaluation is becoming an important indicator of the injury extent or the therapeutic outcomes by reflecting the potential propagation of neural pathways. On the other hand, the repair of damaged nerves is one of the main goals of spinal cord injury treatment. Growing research interest has been concentrated on developing effective therapeutic solutions to restore the normal electrophysiological function of the injured spinal cord by using conductive materials and/or exerting the merits of electrical stimulation. Accordingly, this review introduces the current common electrophysiological evaluation in spinal cord injury. Then the cutting-edge therapeutic strategies aiming at electrophysiological improvement in spinal cord injury are summarized. Finally, the challenges and future prospects of neural restoration after spinal cord injury are presented.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 22","pages":" 5704-5721"},"PeriodicalIF":5.8000,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomaterials Science","FirstCategoryId":"5","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2024/bm/d4bm00959b","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}

引用次数: 0

Abstract

Spinal cord injury is a serious disease of the central nervous system. The electrophysiological properties of the spinal cord that are essential to maintaining neurotransmission can be impaired after the injury. Therefore, electrophysiological evaluation is becoming an important indicator of the injury extent or the therapeutic outcomes by reflecting the potential propagation of neural pathways. On the other hand, the repair of damaged nerves is one of the main goals of spinal cord injury treatment. Growing research interest has been concentrated on developing effective therapeutic solutions to restore the normal electrophysiological function of the injured spinal cord by using conductive materials and/or exerting the merits of electrical stimulation. Accordingly, this review introduces the current common electrophysiological evaluation in spinal cord injury. Then the cutting-edge therapeutic strategies aiming at electrophysiological improvement in spinal cord injury are summarized. Finally, the challenges and future prospects of neural restoration after spinal cord injury are presented.

Abstract Image

查看原文本刊更多论文

电刺激和导电材料：基于电生理学的脊髓损伤治疗。

脊髓损伤是一种严重的中枢神经系统疾病。脊髓的电生理特性对维持神经传导至关重要，而损伤后脊髓的电生理特性可能会受损。因此，通过反映神经通路的潜在传播，电生理评估正成为衡量损伤程度或治疗效果的重要指标。另一方面，修复受损神经是脊髓损伤治疗的主要目标之一。越来越多的研究兴趣集中于开发有效的治疗方案，通过使用导电材料和/或发挥电刺激的优势，恢复受损脊髓的正常电生理功能。因此，本综述介绍了目前脊髓损伤中常见的电生理评估。然后，总结了旨在改善脊髓损伤电生理的前沿治疗策略。最后，介绍了脊髓损伤后神经恢复所面临的挑战和未来前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Biomaterials Science MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

11.50

自引率

4.50%

发文量

556

期刊介绍： Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions.