Mingzhu Ye, Yirui Fan, Caihong Fu, Huixia He and Jianxi Xiao
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引用次数: 0
Abstract
Treating sunburn and other UV-induced skin damage issues remains a significant challenge in the field of dermatology. In this study, we synthesized a highly bioactive recombinant type III collagen (rCol III) to accelerate the healing of UV-damaged skin. The high-purity rCol III demonstrated excellent biocompatibility and bioactivity, significantly promoting the adhesion, proliferation, and migration of HFF-1 cells. In a mouse UV-damage model, Combo evaluations demonstrated that rCol III contributed to restore transepidermal water loss (TEWL) values of UV-damaged skin to normal levels. Histological analysis further confirmed that rCol III substantially accelerated skin repair by enhancing collagen regeneration. Additionally, rCol III facilitated the regeneration of zebrafish tail fin tissue and alleviated shrinkage caused by excessive UV exposure. The biocompatible and bioactive rCol III offers a novel strategy for treating UV-induced skin damage, holding immense potential for applications in skin tissue engineering.
治疗晒伤和其他紫外线引起的皮肤损伤问题仍然是皮肤科领域的一项重大挑战。在这项研究中，我们合成了一种高生物活性的重组 III 型胶原蛋白（rCol III），以加速紫外线损伤皮肤的愈合。高纯度的 rCol III 具有良好的生物相容性和生物活性，能显著促进 HFF-1 细胞的粘附、增殖和迁移。在小鼠紫外线损伤模型中，Combo 评估表明，rCol III 有助于将紫外线损伤皮肤的经表皮失水（TEWL）值恢复到正常水平。组织学分析进一步证实，rCol III 通过促进胶原蛋白再生，大大加快了皮肤修复速度。此外，rCol III 还促进了斑马鱼尾鳍组织的再生，并缓解了过度紫外线照射造成的萎缩。具有生物相容性和生物活性的 rCol III 为治疗紫外线引起的皮肤损伤提供了一种新策略，在皮肤组织工程方面具有巨大的应用潜力。
期刊介绍：
Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions.
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