An efficient and green synthesis of dihydrothiazolo [3,2-a] purine-2 (1H)-one derivatives using bleaching earth clay (BEC) as a recyclable catalyst and study of antibacterial potency

IF 2.2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Prashant P. Mogle, Santosh S. Pohare, Sainath Zangade, Bhaskar S. Dawane
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引用次数: 0

Abstract

The present work described the one-pot multicomponent green and novel protocol for the synthesis of dihydrothiazolo [3,2-a] purine-2(1H)-one derivatives from novel purines and substituted 2-amino-thiazoles using BEC (pH 12.5, 10% by weight) as a recyclable heterogeneous catalyst in environmentally sustainable reaction medium PEG-400. The antibacterial potency was studied using a disc diffusion assay against two bacterial strains such as Staphylococci aureus (MTCC 1430) and Escherichia coli (MTCC 1573). The results of biological tests of newly synthesized derivatives 4a, 4b, 4d, 4g, and 4h display marked antibacterial potency against tested pathogens. The biological relevance of these synthesized derivatives is due to the presence of thiazole nucleus in combination with a purine ring. Further, structure conformation of synthesized titled compounds was presented with different spectroscopic methods such as 1H-NMR, 13C-NMR, IR, and GCMS. Numerous benefits of the current method include the catalyst's recyclability, clean reaction conditions, a quick reaction rate, increased product yield, and the lack of dangerous reagents.

使用漂白土粘土(BEC)作为可回收催化剂高效绿色合成二氢噻唑并[3,2-a]嘌呤-2 (1H)-酮衍生物并研究其抗菌效力
本研究采用 BEC(pH 值为 12.5,重量百分比为 10%)作为可回收的异相催化剂,在环境可持续的反应介质 PEG-400 中,以新型嘌呤和取代的 2-氨基噻唑为原料,合成二氢噻唑并[3,2-a]嘌呤-2(1H)-酮衍生物的单锅多组分绿色新方案。采用盘扩散法研究了其对两种细菌菌株(金黄色葡萄球菌(MTCC 1430)和大肠杆菌(MTCC 1573))的抗菌效力。新合成的衍生物 4a、4b、4d、4g 和 4h 的生物测试结果表明,它们对测试病原体具有明显的抗菌效力。这些合成衍生物的生物学意义在于噻唑核与嘌呤环的结合。此外,还通过不同的光谱方法,如 1H-NMR、13C-NMR、IR 和 GCMS,展示了合成的标题化合物的结构构象。该方法具有催化剂可循环使用、反应条件清洁、反应速度快、产品收率高以及不使用危险试剂等诸多优点。
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来源期刊
CiteScore
4.40
自引率
8.30%
发文量
230
审稿时长
5.6 months
期刊介绍: JICS is an international journal covering general fields of chemistry. JICS welcomes high quality original papers in English dealing with experimental, theoretical and applied research related to all branches of chemistry. These include the fields of analytical, inorganic, organic and physical chemistry as well as the chemical biology area. Review articles discussing specific areas of chemistry of current chemical or biological importance are also published. JICS ensures visibility of your research results to a worldwide audience in science. You are kindly invited to submit your manuscript to the Editor-in-Chief or Regional Editor. All contributions in the form of original papers or short communications will be peer reviewed and published free of charge after acceptance.
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