Omic-driven strategies to unveil microbiome potential for biodegradation of plastics: a review

IF 2.3 3区生物学 Q3 MICROBIOLOGY

Archives of Microbiology Pub Date : 2024-10-21 DOI:10.1007/s00203-024-04165-3

Shafana Farveen Mohamed, Rajnish Narayanan

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引用次数: 0

Abstract

Plastic waste accumulation has lately been identified as the leading and pervasive environmental concern, harming all living beings, natural habitats, and the global market. Given this issue, developing ecologically friendly solutions, such as biodegradation instead of standard disposal, is critical. To effectively address and develop better strategies, it is critical to understand the inter-relationship between microorganisms and plastic, the role of genes and enzymes involved in this process. However, the complex nature of microbial communities and the diverse mechanisms involved in plastic biodegradation have hindered the development of efficient plastic waste degradation strategies. Omics-driven approaches, encompassing genomics, transcriptomics and proteomics have revolutionized our understanding of microbial ecology and biotechnology. Therefore, this review explores the application of omics technologies in plastic degradation studies and discusses the key findings, challenges, and future prospects of omics-based approaches in identifying novel plastic-degrading microorganisms, enzymes, and metabolic pathways. The integration of omics technologies with advanced molecular technologies such as the recombinant DNA technology and synthetic biology would guide in the optimization of microbial consortia and engineering the microbial systems for enhanced plastic biodegradation under various environmental conditions.

Graphical Abstract

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揭示微生物组生物降解塑料潜力的 Omic 驱动战略：综述

最近，塑料废物的积累已被确定为主要的、普遍的环境问题，对所有生物、自然栖息地和全球市场都造成了损害。鉴于这一问题，开发生态友好型解决方案（如生物降解而非标准处理）至关重要。要有效解决这一问题并制定更好的策略，关键是要了解微生物与塑料之间的相互关系，以及参与这一过程的基因和酶的作用。然而，微生物群落的复杂性和塑料生物降解过程中涉及的各种机制阻碍了高效塑料废物降解策略的开发。以 Omics 为驱动的方法，包括基因组学、转录组学和蛋白质组学，彻底改变了我们对微生物生态学和生物技术的理解。因此，本综述探讨了 omics 技术在塑料降解研究中的应用，并讨论了基于 omics 的方法在识别新型塑料降解微生物、酶和代谢途径方面的主要发现、挑战和未来前景。将omics技术与先进的分子技术（如重组DNA技术和合成生物学）相结合，将有助于优化微生物联合体和工程微生物系统，从而在各种环境条件下提高塑料的生物降解能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Microbiology 生物-微生物学

CiteScore

4.90

自引率

3.60%

发文量

601

审稿时长

3 months

期刊介绍： Research papers must make a significant and original contribution to microbiology and be of interest to a broad readership. The results of any experimental approach that meets these objectives are welcome, particularly biochemical, molecular genetic, physiological, and/or physical investigations into microbial cells and their interactions with their environments, including their eukaryotic hosts. Mini-reviews in areas of special topical interest and papers on medical microbiology, ecology and systematics, including description of novel taxa, are also published. Theoretical papers and those that report on the analysis or ''mining'' of data are acceptable in principle if new information, interpretations, or hypotheses emerge.