Salmonella Biomimetic Nanoparticles for Photothermal-Chemotherapy of Colorectal Cancer

IF 9.6 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Letters Pub Date : 2024-10-21 DOI:10.1021/acs.nanolett.4c04609

Ruichi Liu, Yunqiu Miao, Keyi Wen, Yang Yang, Dan Xu, Shengwei Lu, Ziyuan Liu, Huanlong Qin, Xinxin Zhang, Yang Zhang

{"title":"Salmonella Biomimetic Nanoparticles for Photothermal-Chemotherapy of Colorectal Cancer","authors":"Ruichi Liu, Yunqiu Miao, Keyi Wen, Yang Yang, Dan Xu, Shengwei Lu, Ziyuan Liu, Huanlong Qin, Xinxin Zhang, Yang Zhang","doi":"10.1021/acs.nanolett.4c04609","DOIUrl":null,"url":null,"abstract":"Nanomedicines have been widely used in colorectal cancer treatment, but their suboptimal targeting and deficient penetration capabilities remain obstacles in the delivery of therapeutics. In this study, inspired by the natural tumor tropism and intestinal invasion of Salmonella, we engineered highly biomimetic nanoparticles (SM-AuNRs) utilizing a Salmonella membrane to coat bacilliform Au nanorods. The engineered SM-AuNRs were able to mimic the germ’s morphology and biological surface. SM-AuNRs containing the specific proteins inherited from the Salmonella membrane facilitated specific targeting and internalization into tumor cells. Meanwhile, SM-AuNRs with the rod-shaped morphology effectively traversed mucus barriers and tumor stroma. Due to the superior biological barrier penetrating and tumor targeting capabilities, doxorubicin-loaded SM-AuNRs with near-infrared laser irradiation displayed remarkable photothermal-chemotherapeutic antitumor effects in mouse orthotopic colorectal cancer models. Our findings pave the way for the design of bacteria-mimicking nanoparticles, presenting a promising avenue for the targeting and efficient treatment of colorectal cancer.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":null,"pages":null},"PeriodicalIF":9.6000,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano Letters","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1021/acs.nanolett.4c04609","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Nanomedicines have been widely used in colorectal cancer treatment, but their suboptimal targeting and deficient penetration capabilities remain obstacles in the delivery of therapeutics. In this study, inspired by the natural tumor tropism and intestinal invasion of Salmonella, we engineered highly biomimetic nanoparticles (SM-AuNRs) utilizing a Salmonella membrane to coat bacilliform Au nanorods. The engineered SM-AuNRs were able to mimic the germ’s morphology and biological surface. SM-AuNRs containing the specific proteins inherited from the Salmonella membrane facilitated specific targeting and internalization into tumor cells. Meanwhile, SM-AuNRs with the rod-shaped morphology effectively traversed mucus barriers and tumor stroma. Due to the superior biological barrier penetrating and tumor targeting capabilities, doxorubicin-loaded SM-AuNRs with near-infrared laser irradiation displayed remarkable photothermal-chemotherapeutic antitumor effects in mouse orthotopic colorectal cancer models. Our findings pave the way for the design of bacteria-mimicking nanoparticles, presenting a promising avenue for the targeting and efficient treatment of colorectal cancer.

Abstract Image

查看原文本刊更多论文

用于大肠癌光热化疗的沙门氏菌仿生纳米粒子

纳米药物已被广泛应用于结直肠癌的治疗，但其不理想的靶向性和不足的渗透能力仍然是治疗药物输送的障碍。在这项研究中，我们从沙门氏菌的天然肿瘤滋养和肠道侵袭性中得到启发，利用沙门氏菌膜包覆金纳米棒，设计出高度仿生的纳米颗粒（SM-AuNRs）。工程化的 SM-AuNRs 能够模拟病菌的形态和生物表面。SM-AuNRs含有从沙门氏菌膜中继承的特异性蛋白质，有助于特异性靶向和内化到肿瘤细胞中。同时，具有杆状形态的 SM-AuNRs 能有效穿越粘液屏障和肿瘤基质。由于SM-AuNRs具有卓越的生物屏障穿透能力和肿瘤靶向能力，在近红外激光照射下，负载了多柔比星的SM-AuNRs在小鼠正位结直肠癌模型中显示出显著的光热化学治疗抗肿瘤效果。我们的研究结果为设计仿菌纳米粒子铺平了道路，为靶向和高效治疗结直肠癌提供了一条前景广阔的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.