Novel insights and future perspectives on the nanomedicine-mediated synergistic anticancer effect of the combination of ferroptosis and photothermal therapy
Hengkai Qi, Haiying Wang, Lu Wang, Minjie Wei, Zhenhua Li
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引用次数: 0
Abstract
The limitations of existing monotherapies underscore the necessity of exploring innovative synergistic anticancer interventions. Ferroptosis, an iron-dependent form of cell death, is increasingly recognized for its pivotal role in tumor biology and therapeutic strategies. Photothermal therapy (PTT) utilizes near-infrared (NIR) light to induce tumor ablation through heat generation and is a burgeoning area in cancer treatment. Ferroptosis induction generates reactive oxygen species (ROS) and lipid peroxidation (LPO) to enhance the efficacy of mild-temperature PTT. In contrast, photothermal effects can accelerate the rate of the Fenton reaction. Utilizing nanoplatforms such as polymers, metal-phenolic networks (MPNs), hollow mesoporous Prussian blue (HMPB), biocompatible materials, metal-based materials, and metal–organic frameworks (MOFs) can effectively modulate the synergistic effects of ferroptosis and PTT. This review delved into the most recent progress regarding the synergistic interactions between collaborative mechanisms involved in ferroptosis and PTT, as well as the potential integration of these strategies with other treatment modalities. Finally, we have offered insights into the perspectives and challenges associated with the clinical translation of this innovative and promising emerging paradigm.
现有单一疗法的局限性凸显了探索创新协同抗癌干预措施的必要性。铁凋亡是一种依赖铁的细胞死亡形式,它在肿瘤生物学和治疗策略中的关键作用日益得到认可。光热疗法(PTT)利用近红外(NIR)光通过发热诱导肿瘤消融,是癌症治疗的一个新兴领域。铁变态反应诱导产生活性氧(ROS)和脂质过氧化反应(LPO),从而提高低温 PTT 的疗效。相比之下,光热效应可加快芬顿反应的速度。利用聚合物、金属酚网络(MPNs)、中空介孔普鲁士蓝(HMPB)、生物相容性材料、金属基材料和金属有机框架(MOFs)等纳米平台,可以有效地调节铁突变和 PTT 的协同效应。本综述深入探讨了有关铁变态反应和 PTT 协作机制之间协同作用的最新进展,以及这些策略与其他治疗方式的潜在整合。最后,我们还深入探讨了这一创新且前景广阔的新兴范例在临床转化方面的前景和挑战。
期刊介绍:
The Chemical Engineering Journal is an international research journal that invites contributions of original and novel fundamental research. It aims to provide an international platform for presenting original fundamental research, interpretative reviews, and discussions on new developments in chemical engineering. The journal welcomes papers that describe novel theory and its practical application, as well as those that demonstrate the transfer of techniques from other disciplines. It also welcomes reports on carefully conducted experimental work that is soundly interpreted. The main focus of the journal is on original and rigorous research results that have broad significance. The Catalysis section within the Chemical Engineering Journal focuses specifically on Experimental and Theoretical studies in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. These studies have industrial impact on various sectors such as chemicals, energy, materials, foods, healthcare, and environmental protection.