Detection in Orchards of Predominant Azole-Resistant Candida tropicalis Genotype Causing Human Candidemia, Taiwan

IF 7.2 2区医学 Q1 IMMUNOLOGY

Emerging Infectious Diseases Pub Date : 2024-10-19 DOI:10.3201/eid3011.240545

Kuo-Yun Tseng, Yin-Zhi Chen, Zi-Li Zhou, Jyh-Nong Tsai, Min-Nan Tseng, Hsing-Lung Liu, Chi-Jung Wu, Yu-Chieh Liao, Chih-Chao Lin, De-Jiun Tsai, Feng-Jui Chen, Li-Yun Hsieh, Kuan-Chung Huang, Chun-Hua Huang, Kai-Ting Chen, Wen-Li Chu, Chiao-Mei Lin, Shu-Man Shih, Chao Agnes Hsiung, Yee-Chun Chen, Huey-Kang Sytwu, Yun-Liang Yang, Hsiu-Jung Lo

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Abstract

Fluconazole-resistant clade 4 Candida tropicalis causing candidemia in humans has been detected in tropical/subtropical areas, including those in China, Singapore, and Australia. We analyzed 704 individual yeasts isolated from fruits, soil, water, and farmers at 80 orchards in Taiwan. The most common pathogenic yeast species among 251 isolates recovered from farmers were Candida albicans (14.7%) and C. parapsilosis (11.6%). In contrast, C. tropicalis (13.0%), C. palmioleophila (6.6%), and Pichia kudriavzevii (6.0%) were prevalent among 453 environmental isolates. Approximately 18.6% (11/59) of C. tropicalis from the environment were resistant to fluconazole, and 81.8% (9/11) of those belonged to the clade 4 genotype. C. tropicalis susceptibility to fluconazole correlated with susceptibilities to the agricultural azole fungicides, difenoconazole, tebuconazole, and triadimenol. Tandem gene duplications of mutated ERG11 contributed to azole resistance. Agriculture environments are a reservoir for azole-resistant C. tropicalis; discontinuing agricultural use of azoles might reduce emergence of azole-resistant Candida spp. strains in humans.

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在台湾果园中检测到引起人类念珠菌病的主要耐唑热带念珠菌基因型

在热带/亚热带地区，包括中国、新加坡和澳大利亚，发现了耐氟康唑的第 4 支热带念珠菌，它们会导致人类念珠菌血症。我们分析了从台湾 80 个果园的水果、土壤、水和果农中分离出的 704 个酵母菌。在从果农身上分离出的 251 株酵母菌中，最常见的致病酵母菌是白色念珠菌（14.7%）和副酵母菌（11.6%）。相比之下，热带念珠菌（13.0%）、掌叶念珠菌（6.6%）和 Pichia kudriavzevii（6.0%）在 453 个环境分离物中很普遍。环境中约有 18.6%（11/59）的热带真菌对氟康唑具有抗药性，其中 81.8%（9/11）属于第 4 支系基因型。热带真菌对氟环唑的敏感性与对农用唑类杀菌剂二唑醇、戊唑醇和三唑醇的敏感性相关。突变的ERG11的串联基因重复导致了唑类抗性。农业环境是抗唑热带念珠菌的贮藏地；停止在农业环境中使用唑类杀菌剂可能会减少人类中出现抗唑念珠菌菌株。

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.