Lubricin-Inspired Nanozymes Reconstruct Cartilage Lubrication System with an “In-Out” Strategy (Small Methods 10/2024)

Abstract

Inside Front Cover

In article number 2400757, Liao, Huang, Lei, and co-workers developed a novel nanozyme which employs an “In-Out” strategy to restore the cartilage lubrication system. The “Out” aspect aims to decrease friction and minimize the wear and tear on cartilage, while the “In” aspect is focused on alleviating oxidative stress to facilitate the production and secretion of lubricin, thereby enhancing the natural lubrication capacity of cartilage.