Unusual G3P[10] bat-like rotavirus strains detected in children with acute gastroenteritis in Thailand

IF 6.8 3区 医学 Q1 VIROLOGY
Nutthawadee Jampanil, Kattareeya Kumthip, Arpaporn Yodmeeklin, Ratana Tacharoenmuang, Yuki Akari, Satoshi Komoto, Shoko Okitsu, Hiroshi Ushijima, Niwat Maneekarn, Pattara Khamrin
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引用次数: 0

Abstract

Rotavirus A (RVA) is the main cause of acute gastroenteritis among children under the age of five globally. The unusual bat-like human RVA strains G3P[10] (RVA/Human-wt/THA/CMH079/05/2005/G3P[10] and RVA/Human-wt/THA/CMH-S015-19/2019/G3P[10]) were detected in children with acute gastroenteritis in 2005 and 2019, respectively, in the same geographical area of Northern Thailand. To elucidate the genetic backgrounds of these unusual or bat-like human RVA strains, the complete genome of these RVA strains was sequenced and phylogenetically analyzed. All eleven genome segments of these G3P[10] strains were genotyped as G3-P[10]-I8-R3-C3-M3-A9-N3-T3-E3-H6, which is closely related to bat G3P[10] RVA strain (RVA/Bat-tc/CHN/MYAS33/2013/G3P[10]) and bat-like human RVA strain (RVA/Human-wt/THA/MS2015-1-0001/2015/G3P[10]). The findings indicate that human G3P[10] RVA strains detected in this study (RVA/Human-wt/THA/CMH079/05/2005/G3P[10] and RVA/Human-wt/THA/CMH-S015-19/2019/G3P[10]) contained all eleven genome segments similar to those of bat RVA strains and appeared to be human RVA strains of bat origin. Phylogenetic analysis revealed that several genome segments of these two RVA strains were also closely related with those of other species in addition to bats and had a zoonotic transmission history. The results of this study supported the roles of interspecies transmission of RVA strains among bats and humans in the natural environment and provided convincing evidence that the evolution of human RVAs was closely interrelated with those of animal RVAs. Continuing surveillance of RVAs in humans and animals is imperative to gain a better understanding of the origin and the evolution of these viruses.

在泰国急性肠胃炎患儿中发现异常的 G3P[10] 蝙蝠样轮状病毒株
轮状病毒 A(RVA)是全球五岁以下儿童急性肠胃炎的主要病因。2005年和2019年,在泰国北部同一地区的急性肠胃炎患儿中分别发现了不常见的蝙蝠样人类RVA毒株G3P[10](RVA/Human-wt/THA/CMH079/05/2005/G3P[10]和RVA/Human-wt/THA/CMH-S015-19/2019/G3P[10])。为了阐明这些不同寻常或类似蝙蝠的人类 RVA 株系的遗传背景,对这些 RVA 株系的完整基因组进行了测序和系统发育分析。这些G3P[10]菌株的所有11个基因组片段的基因型均为G3-P[10]-I8-R3-C3-M3-A9-N3-T3-E3-H6,与蝙蝠G3P[10]RVA菌株(RVA/Bat-tc/CHN/MYAS33/2013/G3P[10])和蝙蝠样人类RVA菌株(RVA/Human-wt/THA/MS2015-1-0001/2015/G3P[10])密切相关。研究结果表明,本研究检测到的人类 G3P[10] RVA 株系(RVA/Human-wt/THA/CMH079/05/2005/G3P[10]和 RVA/Human-wt/THA/CMH-S015-19/2019/G3P[10])含有与蝙蝠 RVA 株系相似的全部 11 个基因组片段,似乎是源于蝙蝠的人类 RVA 株系。系统发育分析表明,这两种 RVA 株系的多个基因组片段与蝙蝠以外的其他物种的基因组片段也密切相关,并具有人畜共患病传播史。这项研究结果支持了蝙蝠和人类在自然环境中的 RVA 株系种间传播作用,并提供了令人信服的证据,证明人类 RVA 的进化与动物 RVA 的进化密切相关。为了更好地了解这些病毒的起源和进化,继续监测人类和动物中的 RVA 病毒势在必行。
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来源期刊
Journal of Medical Virology
Journal of Medical Virology 医学-病毒学
CiteScore
23.20
自引率
2.40%
发文量
777
审稿时长
1 months
期刊介绍: The Journal of Medical Virology focuses on publishing original scientific papers on both basic and applied research related to viruses that affect humans. The journal publishes reports covering a wide range of topics, including the characterization, diagnosis, epidemiology, immunology, and pathogenesis of human virus infections. It also includes studies on virus morphology, genetics, replication, and interactions with host cells. The intended readership of the journal includes virologists, microbiologists, immunologists, infectious disease specialists, diagnostic laboratory technologists, epidemiologists, hematologists, and cell biologists. The Journal of Medical Virology is indexed and abstracted in various databases, including Abstracts in Anthropology (Sage), CABI, AgBiotech News & Information, National Agricultural Library, Biological Abstracts, Embase, Global Health, Web of Science, Veterinary Bulletin, and others.
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