Revolutionizing nanozyme technology with metal-organic frameworks: Classification, catalytic mechanisms, regulation and applications in biotechnology

IF 13.3 1区工程技术 Q1 ENGINEERING, CHEMICAL

Chemical Engineering Journal Pub Date : 2024-10-18 DOI:10.1016/j.cej.2024.156850

Yiran Wang , Yaqiong Yang , Jiachen Liu , Xiangyu Zi , Huayue Zhu , Xiaolong Sun , Yingjie Miao , Yongqian Fu

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Abstract

Nanozymes, particularly those based on metal–organic frameworks (MOFs), have demonstrated remarkable potential in the biotechnological sector owing to their stability, straightforward synthesis, and exceptional catalytic efficiency. As porous materials, MOFs possess a wealth of active sites that can mimic the functions of natural enzymes, thereby attracting significant interest in the realm of bio-catalysis. Enhancing the catalytic performance of MOF-based nanozymes is crucial for expanding and improving their applications. This paper review comprehensively summarizes the classification, catalytic mechanism, and regulation approaches of MOF-based nanozymes over the past five years. Furthermore, the recent applications in biosensing, antibacterial, anti-cancer, and antioxidant biomedical fields were explored. Lastly, the challenges and prospects of this rapidly evolving field are outlined to stimulate further innovative research and drive its ongoing advancement.

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利用金属有机框架革新纳米酶技术：分类、催化机制、调控和生物技术应用

纳米酶，尤其是基于金属有机框架（MOFs）的纳米酶，由于其稳定性、简单合成和卓越的催化效率，在生物技术领域展现出了巨大的潜力。作为多孔材料，MOFs 具有丰富的活性位点，可以模拟天然酶的功能，因此在生物催化领域备受关注。提高基于 MOF 的纳米酶的催化性能对于扩大和改进其应用至关重要。本文综述了近五年来 MOF 基纳米酶的分类、催化机理和调控方法。此外，还探讨了最近在生物传感、抗菌、抗癌和抗氧化等生物医学领域的应用。最后，概述了这一快速发展的领域所面临的挑战和前景，以激发进一步的创新研究，推动其不断进步。

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来源期刊

Chemical Engineering Journal 工程技术-工程：化工

CiteScore

21.70

自引率

9.30%

发文量

6781

审稿时长

2.4 months

期刊介绍： The Chemical Engineering Journal is an international research journal that invites contributions of original and novel fundamental research. It aims to provide an international platform for presenting original fundamental research, interpretative reviews, and discussions on new developments in chemical engineering. The journal welcomes papers that describe novel theory and its practical application, as well as those that demonstrate the transfer of techniques from other disciplines. It also welcomes reports on carefully conducted experimental work that is soundly interpreted. The main focus of the journal is on original and rigorous research results that have broad significance. The Catalysis section within the Chemical Engineering Journal focuses specifically on Experimental and Theoretical studies in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. These studies have industrial impact on various sectors such as chemicals, energy, materials, foods, healthcare, and environmental protection.