Effect of Elevated Temperatures on Inflammatory Cytokine Release: An In Vitro and Population-Based Study

Environment & Health Pub Date : 2024-05-28 DOI:10.1021/envhealth.4c0005910.1021/envhealth.4c00059

Xiaoxu Hu, Hualing Fu, Luou Zhang, Qian Zhang, Tong Xu, Yangsheng Chen, Guomin Chen, Shuai Jiang, Jiajia Ji, Heidi Qunhui Xie, Li Xu* and Bin Zhao*,

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引用次数: 0

Abstract

Extreme high temperatures in the summer have become a global concern, and their risks to the inflammatory system have been largely unknown. Here we appraised the exposure risks of summer heatwaves by comparing the sera cytokine levels in healthy individuals under high and normal temperatures. In addition, we established a cell model with a 1.5 °C temperature increase to investigate the regulatory mechanisms of temperature-related cytokines. Our results suggest that elevated temperatures enhance the release of interleukin-6 (IL-6) and interleukin-8 (IL-8) via the aryl hydrocarbon receptor (AhR) pathway and augment the pro-inflammatory effects of other factors. This suggests that we may have underestimated the impact of high temperatures on the health of individuals beyond just mortality rates. Moreover, seemingly minor temperature increases of just 1.5 °C can still pose a challenge to cells.

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温度升高对炎症细胞因子释放的影响：体外和人群研究

夏季极端高温已成为全球关注的问题，而其对炎症系统造成的风险在很大程度上还不为人所知。在此，我们通过比较高温和常温下健康人血清中的细胞因子水平，评估了夏季热浪的暴露风险。此外，我们还建立了一个温度升高 1.5°C 的细胞模型，以研究与温度相关的细胞因子的调控机制。我们的研究结果表明，温度升高会通过芳基烃受体（AhR）途径促进白细胞介素-6（IL-6）和白细胞介素-8（IL-8）的释放，并增强其他因子的促炎作用。这表明我们可能低估了高温对个人健康的影响，而不仅仅是死亡率。此外，看似微小的温度升高（仅 1.5 摄氏度）仍会对细胞构成挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environment & Health 环境科学、健康科学-

自引率

0.00%

发文量

期刊介绍： Environment & Health a peer-reviewed open access journal is committed to exploring the relationship between the environment and human health.As a premier journal for multidisciplinary research Environment & Health reports the health consequences for individuals and communities of changing and hazardous environmental factors. In supporting the UN Sustainable Development Goals the journal aims to help formulate policies to create a healthier world.Topics of interest include but are not limited to:Air water and soil pollutionExposomicsEnvironmental epidemiologyInnovative analytical methodology and instrumentation (multi-omics non-target analysis effect-directed analysis high-throughput screening etc.)Environmental toxicology (endocrine disrupting effect neurotoxicity alternative toxicology computational toxicology epigenetic toxicology etc.)Environmental microbiology pathogen and environmental transmission mechanisms of diseasesEnvironmental modeling bioinformatics and artificial intelligenceEmerging contaminants (including plastics engineered nanomaterials etc.)Climate change and related health effectHealth impacts of energy evolution and carbon neutralizationFood and drinking water safetyOccupational exposure and medicineInnovations in environmental technologies for better healthPolicies and international relations concerned with environmental health