Urine Albumin-to-Creatinine Ratio as an Indicator of Brain Activity Changes in Chronic Kidney Disease: A Resting-State fMRI Study

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-10-17 DOI:10.1002/brb3.70106

Yangjie Yu, Jun-Peng Zhang, Zhen Wang, Juan Li, Xu-Yun Hua, Junjie Pan, Rui Dong

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Abstract

Objective

Chronic kidney disease (CKD) is increasingly recognized as a risk factor for alterations in brain function. However, detecting early-stage symptoms and structural changes remains challenging, potentially leading to delayed treatment. In our study, we aimed to investigate spontaneous brain activity changes in CKD patients using resting-state functional magnetic resonance imaging (fMRI). Additionally, we explored the correlation between common biomarkers reflecting CKD severity and brain activity.

Methods

We recruited a cohort of 22 non–dialysis-dependent CKD patients and 22 controls for resting-state fMRI scans. Amplitude of low-frequency fluctuations (ALFFs) and regional homogeneity (ReHo) were calculated to evaluate brain activity. Regression analysis was conducted to explore the correlations between biomarkers reflecting the severity of CKD and brain activity.

Results

CKD patients exhibited reduced z-scored ALFF (zALFF) and mean ALFF (mALFF) in the bilateral putamen, right caudate nucleus, left anterior cingulate, and right precuneus. Changes in bilateral putamen were also found in smCohe-ReHo and szCohe-ReHo analyses. Urine albumin-to-creatinine ratio (UACR), urine protein-to-creatinine ratio (UPCR), and serum albumin levels were associated with attenuated putamen activity.

Conclusion

Non–dialysis-dependent CKD patients had changes in zALFF, mALFF, smCohe-ReHo, and szCohe-ReHo values in specific brain regions, especially bilateral putamen. UACR, UPCR, and serum albumin levels are associated with putamen activity attenuation in rs-fMRI.

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尿白蛋白与肌酐比值作为慢性肾脏病患者大脑活动变化的指标：静息态 fMRI 研究

目的慢性肾脏病（CKD）越来越被认为是导致大脑功能改变的一个危险因素。然而，检测早期症状和结构变化仍具有挑战性，有可能导致治疗延误。在我们的研究中，我们旨在利用静息态功能磁共振成像（fMRI）研究 CKD 患者的自发脑活动变化。此外，我们还探讨了反映 CKD 严重程度的常见生物标志物与大脑活动之间的相关性。方法我们招募了 22 名非透析依赖型 CKD 患者和 22 名对照组患者进行静息状态 fMRI 扫描。计算低频波动振幅（ALFFs）和区域同质性（ReHo）以评估大脑活动。进行回归分析以探讨反映 CKD 严重程度的生物标记物与大脑活动之间的相关性。结果 CKD 患者的双侧丘脑、右侧尾状核、左侧扣带回前区和右侧楔前区的 z 值 ALFF（zALFF）和平均 ALFF（mALFF）均有所降低。在 smCohe-ReHo 和 szCohe-ReHo 分析中也发现了双侧普塔门的变化。尿白蛋白-肌酐比值（UACR）、尿蛋白-肌酐比值（UPCR）和血清白蛋白水平与普塔门活动减弱有关。结论非透析依赖型慢性肾脏病患者特定脑区的 zALFF、mALFF、smCohe-ReHo 和 szCohe-ReHo 值发生了变化，尤其是双侧普坦。UACR、UPCR和血清白蛋白水平与rs-fMRI中的推拿活动衰减有关。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464