Quantitative biomechanical analysis of ureteral obstruction and peristalsis

IF 3.8 2区 工程技术 Q1 ENGINEERING, MECHANICAL
Lin Zhu  (, ), Qiao Li  (, ), Yuanming Gao  (, ), Lizhen Wang  (, ), Yubo Fan  (, )
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Abstract

Malignant ureteral obstruction may lead to renal function damage, renal colic, and infection. The impact of obstructive development on ureteral peristalsis was rarely studied, which requires further investigation. This study used theoretical biomechanical methods to study the motion characteristics of the ureteral wall and obtained the radial motion equation of the ureteral wall. The motion equation was solved by 4–5th order Runge Kutta method. Analyze the motion equation of the ureteral wall, derive the expression for malignant obstructive ureteral pressure, as well as the analytical expressions for radial displacement and circumferential stress of the ureteral wall. By analyzing the radial motion equation of the ureter, it can be found that peristalsis is influenced by the pressure difference between inside and outside. The analytical solutions for radial displacement and stress contained exponential terms. Under the condition of 50% obstruction, the displacement and stress of the ureter were reduced by 90.53% and 81.10%, respectively. This study established the radial motion equation of the ureter and provided analytical solutions for the radial displacement and stress of the obstructed ureter. Based on the radial motion equation of the ureter, the radial motion characteristics of the ureteral wall were explored, including peristalsis and disappearance of peristalsis. This study provided a quantitative relationship between ureteral obstruction and peristalsis. As the degree of obstruction increased, ureteral peristalsis gradually weakened or even disappeared.

输尿管梗阻和蠕动的定量生物力学分析
恶性输尿管梗阻可能导致肾功能损伤、肾绞痛和感染。关于梗阻发展对输尿管蠕动的影响研究很少,这需要进一步研究。本研究采用生物力学理论方法研究了输尿管壁的运动特征,并得到了输尿管壁的径向运动方程。运动方程采用 4-5 阶 Runge Kutta 方法求解。分析输尿管壁的运动方程,推导出恶性梗阻输尿管压力的表达式,以及输尿管壁径向位移和周向应力的解析表达式。通过分析输尿管径向运动方程,可以发现输尿管的蠕动受内外压差的影响。径向位移和应力的解析解包含指数项。在 50%阻塞的条件下,输尿管的位移和应力分别减少了 90.53% 和 81.10%。该研究建立了输尿管径向运动方程,并提供了受阻输尿管径向位移和应力的解析解。根据输尿管径向运动方程,探讨了输尿管壁的径向运动特征,包括蠕动和蠕动消失。这项研究提供了输尿管梗阻与蠕动之间的定量关系。随着梗阻程度的增加,输尿管蠕动逐渐减弱甚至消失。
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来源期刊
Acta Mechanica Sinica
Acta Mechanica Sinica 物理-工程:机械
CiteScore
5.60
自引率
20.00%
发文量
1807
审稿时长
4 months
期刊介绍: Acta Mechanica Sinica, sponsored by the Chinese Society of Theoretical and Applied Mechanics, promotes scientific exchanges and collaboration among Chinese scientists in China and abroad. It features high quality, original papers in all aspects of mechanics and mechanical sciences. Not only does the journal explore the classical subdivisions of theoretical and applied mechanics such as solid and fluid mechanics, it also explores recently emerging areas such as biomechanics and nanomechanics. In addition, the journal investigates analytical, computational, and experimental progresses in all areas of mechanics. Lastly, it encourages research in interdisciplinary subjects, serving as a bridge between mechanics and other branches of engineering and the sciences. In addition to research papers, Acta Mechanica Sinica publishes reviews, notes, experimental techniques, scientific events, and other special topics of interest. Related subjects » Classical Continuum Physics - Computational Intelligence and Complexity - Mechanics
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