UK mosquitoes are competent to transmit Usutu virus at native temperatures

IF 4.1 2区 医学 Q1 INFECTIOUS DISEASES
Jack Pilgrim , Soeren Metelmann , Emma Widlake , Nicola Seechurn , Alexander Vaux , Karen L. Mansfield , Jola Tanianis-Hughes , Ken Sherlock , Nicholas Johnson , Jolyon Medlock , Matthew Baylis , Marcus S.C. Blagrove
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引用次数: 0

Abstract

Usutu virus (USUV) is an emerging zoonotic virus transmitted primarily by Culex mosquitoes. Since its introduction into Europe from Africa during the late 20th century, it has caused mortality within populations of passerine birds and captive owls, and can on occasion lead to disease in humans. USUV was first detected in the UK in 2020 and has become endemic, having been detected in either birds and/or mosquitoes every subsequent year. Importantly, the vector competence of indigenous mosquitoes for the circulating UK (London) USUV strain at representative regional temperatures is still to be elucidated. This study assessed the vector competence of five field-collected mosquito species/biotypes, Culex pipiens biotype molestus, Culex pipiens biotype pipiens, Culex torrentium, Culiseta annulata and Aedes detritus for the London USUV strain, with infection rates (IR) and transmission rates (TR) evaluated between 7 and 28 days post-infection. Infection and transmission were observed in all species/biotypes aside from Ae. detritus and Cx. torrentium. For Cx. pipiens biotype molestus, transmission potential suggests these populations should be monitored further for their role in transmission to humans. Furthermore, both Cx. pipiens biotype pipiens and Cs. annulata were shown to be competent vectors at 19 °C indicating the potential for geographical spread of the virus to other UK regions.
英国蚊子能够在本地温度下传播乌苏图病毒
乌苏图病毒(USUV)是一种新出现的人畜共患病毒,主要通过库蚊传播。自 20 世纪晚期从非洲传入欧洲以来,它已造成雀鸟和人工饲养的猫头鹰种群死亡,有时还会导致人类患病。2020 年,英国首次检测到 USUV,随后每年都在鸟类和/或蚊子中检测到 USUV,现已成为地方病。重要的是,本土蚊子在具有代表性的区域温度下对英国(伦敦)流行的 USUV 株系的病媒能力仍有待阐明。本研究评估了五种野外采集的蚊子物种/生物型(库蚊生物型molestus、库蚊生物型pipiens、库蚊torrentium、Culiseta annulata和伊蚊detritus)对伦敦USUV菌株的媒介能力,评估了感染后7至28天的感染率(IR)和传播率(TR)。除了陨石伊蚊和torrentium伊蚊外,所有物种/生物型都观察到了感染和传播。对于莫氏蝰蛇生物型(Cx. pipiens biotype molestus),传播潜力表明应进一步监测这些种群在向人类传播中的作用。此外,Cx. pipiens 生物型 pipiens 和 Cs. annulata 在 19 °C时都是合格的传播媒介,这表明病毒有可能在英国其他地区传播。
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来源期刊
One Health
One Health Medicine-Infectious Diseases
CiteScore
8.10
自引率
4.00%
发文量
95
审稿时长
18 weeks
期刊介绍: One Health - a Gold Open Access journal. The mission of One Health is to provide a platform for rapid communication of high quality scientific knowledge on inter- and intra-species pathogen transmission, bringing together leading experts in virology, bacteriology, parasitology, mycology, vectors and vector-borne diseases, tropical health, veterinary sciences, pathology, immunology, food safety, mathematical modelling, epidemiology, public health research and emergency preparedness. As a Gold Open Access journal, a fee is payable on acceptance of the paper. Please see the Guide for Authors for more information. Submissions to the following categories are welcome: Virology, Bacteriology, Parasitology, Mycology, Vectors and vector-borne diseases, Co-infections and co-morbidities, Disease spatial surveillance, Modelling, Tropical Health, Discovery, Ecosystem Health, Public Health.
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