Serum albumin level is associated with mortality and hospital stays: A real-world data analysis

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2024-10-11 DOI:10.1016/j.clnesp.2024.10.002

Chao Yang , Juntao Lu , Fang Shen , Hua Xie , Hongyuan Cui , Renying Xu

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引用次数: 0

Abstract

Background & aims

The value of serum albumin might be underestimated, especially in cancer patients. We thus aimed to evaluate the association between serum albumin level at hospital admission and clinical outcomes in hospitalized patients with cancer.

Methods

This is a retrospective, cross-sectional, and real-world data analysis. Hospitalized adult patients with malignant cancer were recruited from two tertiary hospitals. Serum level of albumin, which was measured within 24 h after hospital admission, was the exposure. Length of hospital stays (LOS) was the primary and all-cause in-hospital mortality was the secondary outcomes. Other information, including age, sex, types of cancer, history of hypertension and diabetes, surgery, blood routine test, liver and renal function, and dietary intake, were also abstracted from medical records.

Results

A total number of 5187 adult patients with cancer (2949 were men and 2238 women; average age 61.6 ± 12.4 years and average albumin 40.3 ± 5.2 g/L) were included. The prevalence of hypoalbuminemia was 12.2 % (634/5187). Older patients, patients with liver injury, anemia, and with high level of WBC were positively, while those with overweight and high level of total triglycerides, were negatively associated with hypoalbuminemia. After adjustment of covariates, hypoalbuminemia was significantly associated with longer LOS in the current study. The increase of 5 g/L in serum level of albumin could result in 1.09 days (95%CI: −1.38, −0.80 days) shorter in LOS. The increase of 5 g/L in serum level of albumin was also associated with 45 % lower in risk of mortality (OR = 0.55; 95 % CI: 0.43, 0.7) after fully adjustment.

Conclusions

Serum albumin level at admission was associated with both LOS and mortality in patients with malignant cancer.

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血清白蛋白水平与死亡率和住院时间有关：真实世界数据分析

背景& 目的血清白蛋白的价值可能被低估，尤其是在癌症患者中。因此，我们旨在评估癌症住院患者入院时血清白蛋白水平与临床预后之间的关系。方法这是一项回顾性、横断面和真实世界数据分析。从两家三级医院招募了住院的成年恶性肿瘤患者。入院后 24 小时内测量的血清白蛋白水平是暴露指标。住院时间（LOS）是主要结果，全因住院死亡率是次要结果。其他信息包括年龄、性别、癌症类型、高血压和糖尿病病史、手术、血常规检查、肝肾功能和饮食摄入量等，均来自医疗记录。低白蛋白血症的发生率为 12.2%（634/5187）。老年患者、肝损伤患者、贫血患者和白细胞水平高的患者与低白蛋白血症呈正相关，而超重和总甘油三酯水平高的患者与低白蛋白血症呈负相关。在本研究中，调整协变量后，低白蛋白血症与较长的生命周期显著相关。血清白蛋白水平每增加 5 克/升，患者的生命周期就会缩短 1.09 天（95%CI：-1.38 天，-0.80 天）。结论入院时血清白蛋白水平与恶性肿瘤患者的生命周期和死亡率相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.