Mesenchymal stromal cells surface engineering for efficient hematopoietic reconstitution

IF 12.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Biomaterials Pub Date : 2024-10-10 DOI:10.1016/j.biomaterials.2024.122882

Huiyang Li , Lifei Ma , Ni Zhu , Xiaoyu Liang , Xinxin Tian , Kaijing Liu , Xue Fu , Xiaoli Wang , Hailing Zhang , Houzao Chen , Qiang Liu , Jing Yang

{"title":"Mesenchymal stromal cells surface engineering for efficient hematopoietic reconstitution","authors":"Huiyang Li , Lifei Ma , Ni Zhu , Xiaoyu Liang , Xinxin Tian , Kaijing Liu , Xue Fu , Xiaoli Wang , Hailing Zhang , Houzao Chen , Qiang Liu , Jing Yang","doi":"10.1016/j.biomaterials.2024.122882","DOIUrl":null,"url":null,"abstract":"<div><div>Mesenchymal stromal cells (MSCs) are believed to migrate to injury sites, release chemical attractants, and either recruit local stem cells or modulate the immune system positively. Although MSCs are highly desired for their potential to reduce inflammation and promote tissue regeneration, their limited lifespan restricts their applications. This study presents a simple approach for protecting MSCs with epigallocatechin-3-gallate (EGCG) and magnesium (Mg) based metal-organic framework coatings (E-Mg@MSC). The layer strengthens MSCs resistant to harmful stresses and creates a favorable microenvironment for repair by providing Mg to facilitate MSCs' osteogenic differentiation and using EGCG to neutralize excessive reactive oxygen species (ROS). E-Mg@MSC serves as a treatment for hematopoietic injury induced by ionizing radiation (IR). Coated MSCs exhibit sustained secretion of hematopoietic growth factors and precise homing to radiation-sensitive tissues. In vivo studies show substantial enhancement in hematopoietic system recovery and multi-organ protection. Mechanistic investigations suggest that E-Mg@MSC mitigates IR-induced ROS, cell apoptosis, and ferroptosis, contributing to reduced radiation damage. The system represents a versatile and compelling strategy for cell-surface engineering with functional materials to advance MSCs therapy.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"314 ","pages":"Article 122882"},"PeriodicalIF":12.8000,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomaterials","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0142961224004162","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Mesenchymal stromal cells (MSCs) are believed to migrate to injury sites, release chemical attractants, and either recruit local stem cells or modulate the immune system positively. Although MSCs are highly desired for their potential to reduce inflammation and promote tissue regeneration, their limited lifespan restricts their applications. This study presents a simple approach for protecting MSCs with epigallocatechin-3-gallate (EGCG) and magnesium (Mg) based metal-organic framework coatings (E-Mg@MSC). The layer strengthens MSCs resistant to harmful stresses and creates a favorable microenvironment for repair by providing Mg to facilitate MSCs' osteogenic differentiation and using EGCG to neutralize excessive reactive oxygen species (ROS). E-Mg@MSC serves as a treatment for hematopoietic injury induced by ionizing radiation (IR). Coated MSCs exhibit sustained secretion of hematopoietic growth factors and precise homing to radiation-sensitive tissues. In vivo studies show substantial enhancement in hematopoietic system recovery and multi-organ protection. Mechanistic investigations suggest that E-Mg@MSC mitigates IR-induced ROS, cell apoptosis, and ferroptosis, contributing to reduced radiation damage. The system represents a versatile and compelling strategy for cell-surface engineering with functional materials to advance MSCs therapy.

查看原文本刊更多论文

用于高效造血重建的间充质基质细胞表面工程

间充质基质细胞（MSCs）被认为可迁移到损伤部位，释放化学吸引物，招募当地干细胞或积极调节免疫系统。虽然间充质干细胞因其减少炎症和促进组织再生的潜力而备受青睐，但其有限的寿命限制了其应用。本研究提出了一种利用表没食子儿茶素-3-棓酸盐（EGCG）和镁（Mg）金属有机框架涂层（E-Mg@MSC）保护间充质干细胞的简单方法。通过提供镁来促进间充质干细胞的成骨分化，并利用表没食子儿茶素-3-棓酸盐中和过量的活性氧（ROS），该涂层能增强间充质干细胞对有害应力的抵抗力，并为修复创造有利的微环境。E-Mg@MSC 可用于治疗电离辐射（IR）引起的造血损伤。有涂层的间充质干细胞能持续分泌造血生长因子，并精确地向辐射敏感组织归巢。体内研究显示，造血系统的恢复和多器官保护能力大大增强。机理研究表明，E-Mg@MSC 可减轻红外诱导的 ROS、细胞凋亡和铁变态反应，从而减少辐射损伤。该系统代表了利用功能材料进行细胞表面工程以促进间充质干细胞治疗的一种多功能且引人注目的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Biomaterials 工程技术-材料科学：生物材料

CiteScore

26.00

自引率

2.90%

发文量

565

审稿时长

46 days

期刊介绍： Biomaterials is an international journal covering the science and clinical application of biomaterials. A biomaterial is now defined as a substance that has been engineered to take a form which, alone or as part of a complex system, is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnostic procedure. It is the aim of the journal to provide a peer-reviewed forum for the publication of original papers and authoritative review and opinion papers dealing with the most important issues facing the use of biomaterials in clinical practice. The scope of the journal covers the wide range of physical, biological and chemical sciences that underpin the design of biomaterials and the clinical disciplines in which they are used. These sciences include polymer synthesis and characterization, drug and gene vector design, the biology of the host response, immunology and toxicology and self assembly at the nanoscale. Clinical applications include the therapies of medical technology and regenerative medicine in all clinical disciplines, and diagnostic systems that reply on innovative contrast and sensing agents. The journal is relevant to areas such as cancer diagnosis and therapy, implantable devices, drug delivery systems, gene vectors, bionanotechnology and tissue engineering.