Running-based food aversion learning in freely-fed and hydrated rats: Daily monitoring of running-induced nausea by measuring kaolin clay ingestion

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior Pub Date : 2024-10-11 DOI:10.1016/j.physbeh.2024.114715

Sadahiko Nakajima

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引用次数: 0

Abstract

The main objective of this research was to demonstrate food aversion learning in rats with unrestricted access to food and water, using wheel running as the unconditioned stimulus. Experiment 1 showed that the target-running paired training group consumed a statistically smaller amount of the target food (tteok rice cakes) compared to the target/running unpaired control group, but the decrease in consumption over days in the paired group was not fully supported by a statistical test. Experiment 2a improved the methodology by familiarizing rats with tteok before training, which resulted in both a statistically significant group effect and a statistically significant daily decrease in tteok consumption. Experiment 2b demonstrated that tteok aversion could be reacquired after an extinction phase. These experiments indicate that running-based tteok aversion in non-deprived rats is a valid example of Pavlovian conditioning and suggest that wheel running can cause similar effects in unrestricted rats as observed in food- or water-restricted rats. Additionally, daily measurements of kaolin clay ingestion suggested that wheel running induced nausea in the rats of these experiments.

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自由进食和水合大鼠基于奔跑的食物厌恶学习通过测量高岭土摄入量监测跑步诱发恶心的日常情况

这项研究的主要目的是以车轮奔跑作为非条件刺激，证明大鼠在不受限制地获取食物和水的情况下进行食物厌恶学习。实验 1 显示，与目标/奔跑未配对的对照组相比，目标-奔跑配对训练组的目标食物（德叔年糕）消耗量在统计学上较小，但配对组消耗量在数天内的减少并没有得到统计学检验的充分支持。实验 2a 改进了实验方法，在训练前让大鼠熟悉德谷，结果在统计学上产生了显著的组间效应，并且在统计学上显著降低了德谷的日消耗量。实验 2b 表明，在经过消退阶段后，大鼠可以重新获得对德谷的厌恶感。这些实验表明，非剥夺性大鼠基于奔跑的手托厌恶是巴甫洛夫条件反射的一个有效例子，并表明车轮奔跑可以在非限制性大鼠身上产生与食物或水限制性大鼠类似的效果。此外，每天对高岭土摄入量的测量表明，在这些实验中，车轮跑会引起大鼠恶心。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physiology & Behavior 医学-行为科学

CiteScore

5.70

自引率

3.40%

发文量

274

审稿时长

47 days

期刊介绍： Physiology & Behavior is aimed at the causal physiological mechanisms of behavior and its modulation by environmental factors. The journal invites original reports in the broad area of behavioral and cognitive neuroscience, in which at least one variable is physiological and the primary emphasis and theoretical context are behavioral. The range of subjects includes behavioral neuroendocrinology, psychoneuroimmunology, learning and memory, ingestion, social behavior, and studies related to the mechanisms of psychopathology. Contemporary reviews and theoretical articles are welcomed and the Editors invite such proposals from interested authors.