Modulation effects of repetitive transcranial magnetic stimulation on target and indirect target nodes in patients with major depressive disorder

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2024-10-12 DOI:10.1016/j.jpsychires.2024.10.012

Jiayu Pan , Keming Ren , Jiashu Yao , Jiangwei Chen , Qing Fang , Jian Pan , Qiu Ge , Wei Chen , Yuedi Shen

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引用次数: 0

Abstract

Clinical studies intensively highlight two critical brain regions, i,e, dorsal lateral prefrontal cortex (DLPFC) (target node) and subgenual anterior cingulate cortex (sgACC) (indirect target node) for the treatment of neuroimaging-guided repetitive transcranial magnetic stimulation (rTMS) in major depressive disorder (MDD). However, it remains unclear whether the clinical rTMS treatment could modulate the activity of the target and indirect target nodes in MDD patients. We aim to identify the rTMS-induced alteration of brain local and functional connectivity (FC) activities in the target and indirect target nodes. 38 patients with MDD were recruited for taking part in the 2-week rTMS treatment. We identified left DLPFC and right sgACC as the target and indirect target nodes for each participant, using the neuroimaging guided method, and further explored the rTMS-induced modulation on the brain functional activity of the two nodes. Ultimately, 28 patients were included in the analysis. We found that subjects had significant improvement in depressive symptoms, and their brain functional activities were reorganized. rTMS reduced the FC activity between the target and indirect target nodes, while the brain local activity in these nodes did not show rTMS-induced changes. The FC reduction was not associated with improvement in depressive symptoms. These results confirmed the clinical significance of the target node (DLPFC) and indirect target node (sgACC) in the rTMS treatment of MDD, and further shed light on the brain functional reorganization underpinning clinical practice of rTMS.

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重复经颅磁刺激对重度抑郁障碍患者靶节点和间接靶节点的调节作用

临床研究着重强调了神经影像引导的重复经颅磁刺激（rTMS）治疗重度抑郁症（MDD）的两个关键脑区，即背外侧前额叶皮层（DLPFC）（目标节点）和前扣带回下皮层（sgACC）（间接目标节点）。然而，临床经颅磁刺激治疗是否能调节 MDD 患者的靶节点和间接靶节点的活动仍不清楚。我们旨在确定经颅磁刺激引起的目标和间接目标节点的大脑局部和功能连接（FC）活动的改变。我们招募了 38 名 MDD 患者参加为期 2 周的经颅磁刺激治疗。我们利用神经影像引导法确定了每位患者的左侧DLPFC和右侧sgACC为目标和间接目标节点，并进一步探讨了经颅磁刺激对这两个节点的大脑功能活动的调节。最终，28 名患者被纳入分析。我们发现，受试者的抑郁症状得到了明显改善，大脑功能活动也得到了重组。经颅磁刺激减少了目标节点和间接目标节点之间的FC活动，而这些节点的大脑局部活动并未出现经颅磁刺激诱导的变化。FC的减少与抑郁症状的改善无关。这些结果证实了目标节点（DLPFC）和间接目标节点（sgACC）在经频磁刺激治疗MDD中的临床意义，并进一步揭示了经颅磁刺激临床实践中的脑功能重组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;