Frontoparietal network integrity supports cognitive function in pre-symptomatic frontotemporal dementia: Multimodal analysis of brain function, structure, and perfusion

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2024-10-17 DOI:10.1002/alz.14299

Xulin Liu, Peter Simon Jones, Maurice Pasternak, Mario Masellis, Arabella Bouzigues, Lucy L. Russell, Phoebe H. Foster, Eve Ferry-Bolder, John van Swieten, Lize Jiskoot, Harro Seelaar, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Pietro Tiraboschi, Isabel Santana, Alexander Gerhard, Johannes Levin, Sandro Sorbi, Markus Otto, Florence Pasquier, Simon Ducharme, Chris Butler, Isabelle Le Ber, Elizabeth Finger, Maria Carmela Tartaglia, Matthis Synofzik, Fermin Moreno, Barbara Borroni, Jonathan D. Rohrer, Kamen A. Tsvetanov, James B. Rowe

引用次数: 0

Abstract

Genetic mutation carriers of frontotemporal dementia can remain cognitively well despite neurodegeneration. A better understanding of brain structural, perfusion, and functional patterns in the pre-symptomatic stage could inform accurate staging and potential mechanisms.

查看原文本刊更多论文

额顶网络的完整性支持症状前额颞叶痴呆症患者的认知功能：大脑功能、结构和灌注的多模态分析

额颞叶痴呆的基因突变携带者尽管神经退化，但认知能力仍然良好。更好地了解无症状前阶段的大脑结构、灌注和功能模式，可以为准确分期和潜在机制提供依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.