Drug origami: A computation-guided approach for customizable drug release kinetics of oral formulations

IF 17.3 1区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Matter Pub Date : 2024-10-17 DOI:10.1016/j.matt.2024.09.022
Hao Huang, Haoyu Zhang, Ningjie Du, Yidan Lyu, Jiahang Xu, Haoran Fu, Yixin Guan, Kewang Nan
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引用次数: 0

Abstract

Despite the prolonged therapeutic benefits offered by many existing extended-release oral drug formulations, their inability to conform to circadian rhythms and specific pathological profiles remains a critical limitation. Here, we report drug origami, a computation-guided, origami-inspired approach for modulating the drug release kinetics of oral formulations. By harnessing the precise folding patterns of origami, the drug origami demonstrates characteristics of pulsatile and multiphasic release that can be tailored to match specific medication regimens. By employing computational models guided by control equations, both in vitro and in vivo drug release kinetics can be predicted and modulated with good quantitative agreement. This and other evidence suggest drug origami to be “do-it-yourself” drugs in personalized medicine where patients can create their own formulations according to individual medical needs.

Abstract Image

药物折纸:计算指导下的口服制剂药物释放动力学定制方法
尽管许多现有的缓释口服药物制剂具有延长治疗时间的优点,但它们无法适应昼夜节律和特定病理特征仍然是一个关键的限制因素。在此,我们报告了药物折纸,这是一种由计算引导、受折纸启发的调节口服制剂药物释放动力学的方法。通过利用折纸的精确折叠模式,药物折纸显示出脉冲式和多相释放的特点,可根据特定的用药方案进行定制。通过采用以控制方程为指导的计算模型,体外和体内药物释放动力学均可预测和调控,并具有良好的定量一致性。这和其他证据表明,药物折纸是个性化医疗中的 "自己动手 "药物,患者可以根据个人医疗需求创造自己的配方。
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来源期刊
Matter
Matter MATERIALS SCIENCE, MULTIDISCIPLINARY-
CiteScore
26.30
自引率
2.60%
发文量
367
期刊介绍: Matter, a monthly journal affiliated with Cell, spans the broad field of materials science from nano to macro levels,covering fundamentals to applications. Embracing groundbreaking technologies,it includes full-length research articles,reviews, perspectives,previews, opinions, personnel stories, and general editorial content. Matter aims to be the primary resource for researchers in academia and industry, inspiring the next generation of materials scientists.
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