Cover Feature: Photoactivated Anticancer Activity of Cobalt(III) Complexes with Naturally Occurring Flavonoids Chrysin and Silibinin (ChemBioChem 20/2024)

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

ChemBioChem Pub Date : 2024-10-16 DOI:10.1002/cbic.202482002

Jyotirmoy Dutta, Arpan Bera, Aarti Upadhyay, Ashish Kumar Yadav, Samya Banerjee, Tukki Sarkar, Akhtar Hussain

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Abstract

The article 10.1002/cbic.202400484 by Samya Banerjee, Tukki Sarkar, Akhtar Hussain, and co-workers highlights the synthesis, characterization, and evaluation of six new mixed-ligand cobalt(III) complexes for photodynamic therapy (PDT) in cancer treatment. Notably, complexes Co5 and Co6, featuring dipyridophenazine and the naturally occurring flavonoids chrysin and silibinin, exhibit significant toxicity against cervical and lung cancer cells under visible light with low micromolar IC₅₀ values, while showing minimal toxicity in the absence of light. These complexes induce apoptosis via singlet oxygen generation following a type-II PDT pathway, displaying remarkable selectivity and biocompatibility for potential cancer PDT applications.

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封面专题：钴（III）与天然黄酮类化合物 Chrysin 和 Silibinin 的光活化抗癌活性（ChemBioChem 20/2024）

Samya Banerjee、Tukki Sarkar、Akhtar Hussain 及合作者撰写的 10.1002/cbic.202400484 号文章重点介绍了用于癌症光动力疗法（PDT）的六种新型混合配体钴（III）配合物的合成、表征和评估。值得注意的是，Co5 和 Co6 复合物具有二哒嗪和天然黄酮类化合物菊黄素和丝核苷，在可见光下对宫颈癌和肺癌细胞有显著毒性，IC50 值低至微摩尔，而在无光条件下毒性极小。这些复合物通过单线态氧的生成诱导细胞凋亡，遵循第二型光致褪色疗法途径，具有显著的选择性和生物相容性，可用于潜在的癌症光致褪色疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemBioChem 生物-生化与分子生物学

CiteScore

6.10

自引率

3.10%

发文量

407

审稿时长

1 months

期刊介绍： ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).