Fluorescence turn-off detection of myoglobin as a cardiac biomarker using water-stable L-glutamic acid functionalized cesium lead bromide perovskite quantum dots

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchimica Acta Pub Date : 2024-10-16 DOI:10.1007/s00604-024-06752-z

Bhargava Thamminana, Mayurkumar Revabhai Patel, Madhura Pradeep Deshpande, Tae Jung Park, Suresh Kumar Kailasa

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Abstract

Water dispersible L-glutamic acid (Glu) functionalized cesium lead bromide perovskite quantum dots (CsPbBr₃ PQDs), namely CsPbBr₃@Glu PQDs were synthesized and used for the fluorescence “turn-off” detection of myoglobin (Myo). The as-prepared CsPbBr₃@Glu PQDs exhibited an exceptional photoluminescence quantum yield of 25% and displayed emission peak at 520 nm when excited at 380 nm. Interestingly, the fluorescence “turn-off” analytical approach was designed to detect Myo using CsPbBr₃@Glu PQDs as a simple optical probe. The developed probe exhibited a wide linear range (0.1–25 µM) and a detection limit of 42.42 nM for Myo sensing. The CsPbBr₃@Glu PQDs-based optical probe provides high ability to determine Myo in serum and plasma samples.

Graphical Abstract

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利用水稳定的 L-谷氨酸功能化溴化铯铅包晶量子点荧光猝灭检测作为心脏生物标记物的肌红蛋白

合成了水分散型 L-谷氨酸（Glu）功能化铯溴铅包晶石量子点（CsPbBr3 PQDs），即 CsPbBr3@Glu PQDs，并将其用于肌红蛋白（Myo）的荧光 "熄灭 "检测。所制备的 CsPbBr3@Glu PQDs 的光量子产率高达 25%，在 380 纳米波长下激发时，发射峰在 520 纳米波长处。有趣的是，利用 CsPbBr3@Glu PQDs 作为简单的光学探针，设计了一种荧光 "关闭 "分析方法来检测 Myo。所开发的探针对 Myo 的检测具有较宽的线性范围（0.1-25 µM）和 42.42 nM 的检测限。基于CsPbBr3@Glu PQDs的光学探针具有很强的检测血清和血浆样品中Myo的能力。图摘

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.