Multimodal ultrasound assessment of mass and non-mass enhancements by MRI: Diagnostic accuracy in idiopathic granulomatous mastitis and breast cancer

IF 5.7 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast Pub Date : 2024-09-12 DOI:10.1016/j.breast.2024.103797

Liang Yin , Xi Wei , Qing Zhang , Lingling Xiang , Yun Zhang , Deqian Wang , Peiqin Chen , Xuan Cao , Zakari Shaibu , Rong Qin

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引用次数: 0

Abstract

Purpose

Idiopathic granulomatous mastitis (IGM) poses diagnostic challenges due to its diverse clinical and radiological presentations, often mimicking malignancies. This study aimed to assess the diagnostic efficacy of multimodal ultrasound for mass and non-mass enhancements in Dynamic Contrast-Enhanced MRI (DCE-MRI) of IGM and breast cancer.

Methods

A retrospective analysis involved patients confirmed histopathologically with IGM and BC. All patients underwent conventional ultrasound (C-US), ultrasound elastography (UE), contrast-enhanced ultrasound (CEUS), and DCE-MRI examinations. Blinded experienced radiologists assessed imaging findings. Diagnostic accuracy, sensitivity, and specificity were calculated for mass and non-mass enhancements.

Results

For mass enhancements (ME), multimodal ultrasound demonstrated strong efficacy (AUC = 0.8651, 95 % CI: 0.7431 to 0.9871), exhibiting high sensitivity (83.3 %) and specificity (92.4 %) in differentiating IGM from breast cancer. However, for non-mass enhancements (NME), multimodal ultrasound showed limited accuracy (AUC = 0.6306) with lower sensitivity (65.6 %) and specificity (81.2 %) in distinguishing between IGM and breast cancer.

Conclusion

Multimodal ultrasound displayed good diagnostic efficacy for mass enhancements in DCE-MRI for IGM and breast cancer, while for non-mass enhancement patterns, DCE-MRI remains the most valuable radiological modality for comprehensively assessing this condition's complexities.

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核磁共振成像对肿块和非肿块增强的多模态超声评估：特发性肉芽肿性乳腺炎和乳腺癌的诊断准确性

目的特发性肉芽肿性乳腺炎（IGM）的临床和放射学表现多种多样，常常与恶性肿瘤相似，因此给诊断带来了挑战。本研究旨在评估多模态超声对IGM和乳腺癌动态对比增强磁共振成像（DCE-MRI）中肿块和非肿块增强的诊断效果。所有患者均接受了常规超声（C-US）、超声弹性成像（UE）、对比增强超声（CEUS）和 DCE-MRI 检查。经验丰富的双盲放射科医生对成像结果进行评估。结果对于肿块增强（ME），多模态超声显示出很强的疗效（AUC = 0.8651，95 % CI：0.7431 至 0.9871），在区分 IGM 和乳腺癌方面表现出很高的灵敏度（83.3 %）和特异性（92.4 %）。结论：多模态超声显示出了良好的诊断效果，可用于DCE-MRI中IGM和乳腺癌的肿块增强，而对于非肿块增强模式，DCE-MRI仍是全面评估该病症复杂性的最有价值的放射模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast 医学-妇产科学

CiteScore

8.70

自引率

2.60%

发文量

165

审稿时长

59 days

期刊介绍： The Breast is an international, multidisciplinary journal for researchers and clinicians, which focuses on translational and clinical research for the advancement of breast cancer prevention, diagnosis and treatment of all stages.