Receptor tyrosine kinases and steroid hormone receptors in breast cancer: Review of recent evidences

Metabolism open Pub Date : 2024-10-16 DOI:10.1016/j.metop.2024.100324

Awgichew Behaile Teklemariam , Zelalem Tilahun Muche , Melaku Mekonnen Agidew , Anemut Tilahun Mulu , Edgeit Abebe Zewde , Nega Dagnew Baye , Dagnew Getnet Adugna , Lemlemu Maru , Teklie Mengie Ayele

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Abstract

Breast cancer development and progression are driven by intricate networks involving receptor tyrosine kinases (RTKs) and steroid hormone receptors specifically estrogen receptor (ER) and progesterone receptor (PR). This review examined roles of each receptor under normal physiology and in breast cancer, and explored their multifaceted interactions via signaling pathways, focusing on their contributions to breast cancer progression. Since defining the mechanism by which these two-receptor mediated signaling pathways cooperate is essential for understanding breast cancer progression, we discussed the mechanisms of cross-talk between RTKs and ER and PR and their potential therapeutic implications as well. The crosstalk between RTKs and steroid hormone receptors (ER and PR) in breast cancer can influence the disease's progression and treatment outcomes. Therefore, understanding the functions of the aforementioned receptors and their interactions is crucial for developing effective therapies.

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乳腺癌中的受体酪氨酸激酶和类固醇激素受体：最新证据综述

受体酪氨酸激酶（RTKs）和类固醇激素受体（特别是雌激素受体（ER）和孕酮受体（PR））组成的复杂网络驱动着乳腺癌的发生和发展。这篇综述探讨了每种受体在正常生理情况下和乳腺癌中的作用，并通过信号通路探讨了它们多方面的相互作用，重点关注它们对乳腺癌进展的贡献。由于确定这两种受体介导的信号通路的合作机制对于理解乳腺癌的进展至关重要，因此我们讨论了 RTK 与 ER 和 PR 之间的交叉作用机制及其潜在的治疗意义。乳腺癌中 RTKs 与类固醇激素受体（ER 和 PR）之间的相互作用会影响疾病的进展和治疗效果。因此，了解上述受体的功能及其相互作用对于开发有效的疗法至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolism open Agricultural and Biological Sciences (General), Endocrinology, Endocrinology, Diabetes and Metabolism

自引率

0.00%

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审稿时长

40 days