High endothelial venules in the pleura: MECA-79 expression in mesothelioma, pleural metastasis and pleuritis

IF 2.9 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2024-10-15 DOI:10.1016/j.prp.2024.155661

Ikram Kherrour , Mousa Mobarki , Michel Péoc’h , Georgia Karpathiou

{"title":"High endothelial venules in the pleura: MECA-79 expression in mesothelioma, pleural metastasis and pleuritis","authors":"Ikram Kherrour , Mousa Mobarki , Michel Péoc’h , Georgia Karpathiou","doi":"10.1016/j.prp.2024.155661","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>High endothelial venules (HEVs) are vessels specialized in the extravasation of lymphocytes from the blood to the tissue implicated in the immune microenvironment of several tumors. Their presence has been never studied in the pleural tissue.</div></div><div><h3>Material and methods</h3><div>We retrospectively studied 149 surgical pleural biopsies by immunohistochemistry for MECA-79 expression, a marker specifically recognizing HEVs. The tissues included 44 (44 %) inflammatory and 105 (56 %) neoplastic diseases. The latter corresponded to 34 (22.8 %) mesotheliomas and 71 (47.7 %) metastases from lung (n=50) or breast (n=21) primaries.</div></div><div><h3>Results</h3><div>HEVs were present in 102 (68 %) of all pleural specimens with a mean number of foci containing HEVs of 13.33 (±20.64). Neoplastic pleural pathologies harbored HEVs in 73.3 % of the cases compared to the non-neoplastic pathologies which harbored HEVs in 56.8 % of the cases (p=0.048). Their presence did not differ between pulmonary or mammary metastasis (p=0.7).</div></div><div><h3>Conclusion</h3><div>We show for the first time that HEVs are present in the pleural cavity probably participating in the immune microenvironment of inflammatory and neoplastic pleural disease.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pathology, research and practice","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0344033824005727","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PATHOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

High endothelial venules (HEVs) are vessels specialized in the extravasation of lymphocytes from the blood to the tissue implicated in the immune microenvironment of several tumors. Their presence has been never studied in the pleural tissue.

Material and methods

We retrospectively studied 149 surgical pleural biopsies by immunohistochemistry for MECA-79 expression, a marker specifically recognizing HEVs. The tissues included 44 (44 %) inflammatory and 105 (56 %) neoplastic diseases. The latter corresponded to 34 (22.8 %) mesotheliomas and 71 (47.7 %) metastases from lung (n=50) or breast (n=21) primaries.

Results

HEVs were present in 102 (68 %) of all pleural specimens with a mean number of foci containing HEVs of 13.33 (±20.64). Neoplastic pleural pathologies harbored HEVs in 73.3 % of the cases compared to the non-neoplastic pathologies which harbored HEVs in 56.8 % of the cases (p=0.048). Their presence did not differ between pulmonary or mammary metastasis (p=0.7).

Conclusion

We show for the first time that HEVs are present in the pleural cavity probably participating in the immune microenvironment of inflammatory and neoplastic pleural disease.

查看原文本刊更多论文

胸膜中的高内皮静脉：间皮瘤、胸膜转移和胸膜炎中的 MECA-79 表达

导言高内皮细胞静脉（HEVs）是专门用于淋巴细胞从血液外渗到组织的血管，与多种肿瘤的免疫微环境有关。材料与方法我们对 149 例手术胸膜活检组织进行了回顾性研究，用免疫组化方法检测了 MECA-79 的表达，这是一种能特异性识别 HEV 的标记物。这些组织包括 44 例（44%）炎症性疾病和 105 例（56%）肿瘤性疾病。后者包括 34 例（22.8%）间皮瘤和 71 例（47.7%）肺部（n=50）或乳腺（n=21）原发灶转移瘤。结果所有胸膜标本中有 102 例（68%）存在 HEV，含有 HEV 的病灶平均数量为 13.33（±20.64）个。肿瘤性胸膜病变中有73.3%的病例中含有HEV，而非肿瘤性病变中有56.8%的病例中含有HEV（P=0.048）。结论我们首次发现 HEVs 存在于胸膜腔中，可能参与了炎症性和肿瘤性胸膜疾病的免疫微环境。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.