The guanylate-binding protein GBP1 forms a protein coat that enwraps cytosol-invasive bacteria

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2024-10-15 DOI:10.1038/s41594-024-01403-6

引用次数: 0

Abstract

GBP1 is an important innate immunity component that contributes to the control of cytosol-invasive bacterial pathogens. Using cryo-electron microscopy (cryo-EM), cryo-electron tomography (cryo-ET) and biophysical assays, we show how GBP1 oligomers enwrap and remodel the lipopolysaccharide (LPS)-containing membrane of gram-negative bacterial pathogens.

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鸟苷酸结合蛋白 GBP1 形成包裹细胞膜入侵细菌的蛋白外衣

GBP1 是一种重要的先天性免疫成分，有助于控制细胞膜侵入性细菌病原体。我们利用低温电子显微镜（cryo-EM）、低温电子断层扫描（cryo-ET）和生物物理实验，展示了 GBP1 寡聚体如何包裹和重塑革兰氏阴性细菌病原体的含脂多糖（LPS）膜。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.