Yi Deng, Xiaoke Lian, Zhijie Lin, Dan Sun, Haiyang Zou, Yau Kei Chan, Weizhong Yang, Miaomiao He, Guangfu Yin
{"title":"Engineered Multifunctional BioHJzyme via Tuning D-Band Center for Postoperative Infected Wound Regeneration of Tumor Resection","authors":"Yi Deng, Xiaoke Lian, Zhijie Lin, Dan Sun, Haiyang Zou, Yau Kei Chan, Weizhong Yang, Miaomiao He, Guangfu Yin","doi":"10.1002/adfm.202414823","DOIUrl":null,"url":null,"abstract":"The catalytic therapy for abundant •OH, <sup>1</sup>O<sub>2</sub>, and •O<sub>2</sub><sup>−</sup> provides an efficient tactic and methodology for rapid tumor/bacteria killing, whereas the limitation is focused on the catalytic efficiency owing to the in-built energy band of catalytic materials. Thus, d-band center tuning BioHJzyme is devised, which is composed of zinc tellurate/manganese dioxide anchored by glucose oxidase (GOx) with anti-tumor and anti-bacteria properties for postoperative infected wound regeneration of tumor. The GOx depletes glucose to produce H<sub>2</sub>O<sub>2</sub>, intercepting the glucose metabolism. The D-BioHJzyme can catalyze the produced H<sub>2</sub>O<sub>2</sub> to highly lethal •OH with POD-mimetic activity owing to the tunned d-band center strategy decreasing the adsorption energy of the intermediate in the catalytical process, while the oxygen originated from H<sub>2</sub>O<sub>2</sub> and Mn<sup>2+</sup> can be catalyzed into <sup>1</sup>O<sub>2</sub>. The GPx-mimetic activity of it can impair the antioxidant system of tumor. In vivo studies show that the BioHJzyme exhibits robust abilities against bacteria and tumors by •OH/<sup>1</sup>O<sub>2</sub> production and promotes the apoptosis owing the Te. Besides, the BioHJzyme can accelerate cutaneous regeneration by M1/M2 regulation and the angiogenesis/collagen deposition. This work enlightens a powerful platform for the remedy of postoperative infected wound regeneration of tumor resection using an engineered BioHJzyme.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":null,"pages":null},"PeriodicalIF":18.5000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Functional Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1002/adfm.202414823","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The catalytic therapy for abundant •OH, 1O2, and •O2− provides an efficient tactic and methodology for rapid tumor/bacteria killing, whereas the limitation is focused on the catalytic efficiency owing to the in-built energy band of catalytic materials. Thus, d-band center tuning BioHJzyme is devised, which is composed of zinc tellurate/manganese dioxide anchored by glucose oxidase (GOx) with anti-tumor and anti-bacteria properties for postoperative infected wound regeneration of tumor. The GOx depletes glucose to produce H2O2, intercepting the glucose metabolism. The D-BioHJzyme can catalyze the produced H2O2 to highly lethal •OH with POD-mimetic activity owing to the tunned d-band center strategy decreasing the adsorption energy of the intermediate in the catalytical process, while the oxygen originated from H2O2 and Mn2+ can be catalyzed into 1O2. The GPx-mimetic activity of it can impair the antioxidant system of tumor. In vivo studies show that the BioHJzyme exhibits robust abilities against bacteria and tumors by •OH/1O2 production and promotes the apoptosis owing the Te. Besides, the BioHJzyme can accelerate cutaneous regeneration by M1/M2 regulation and the angiogenesis/collagen deposition. This work enlightens a powerful platform for the remedy of postoperative infected wound regeneration of tumor resection using an engineered BioHJzyme.
期刊介绍:
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