Spatial cytokine microniches direct T helper cell pathways that drive allergic asthma

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2024-10-16 DOI:10.1038/s41590-024-01987-7

引用次数: 0

Abstract

Using temporal and spatial tracking of allergen-specific T cells, we describe the gene regulatory networks that drive T helper 2 cells (TH2 cells) to develop in response to allergens. Spatial microniches of IL-2 in lymph nodes supported the earliest TH2 cells, demonstrating lymph node localization is a driver of TH2 cell initiation.

Abstract Image

查看原文本刊更多论文

空间细胞因子微环引导 T 辅助细胞通路，驱动过敏性哮喘的发生

通过对过敏原特异性 T 细胞的时间和空间追踪，我们描述了驱动 T 辅助 2 细胞（TH2 细胞）发育以应对过敏原的基因调控网络。淋巴结中的IL-2空间微粒支持最早的TH2细胞，证明淋巴结定位是TH2细胞启动的驱动力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.