The risk of attention deficit hyperactivity disorder symptoms in offspring of mothers with perinatal depression: A systematic review and meta-analysis

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry Pub Date : 2024-10-10 DOI:10.1016/j.ajp.2024.104261

Biruk Shalmeno Tusa , Rosa Alati , Getinet Ayano , Kim Betts , Adisu Birhanu Weldesenbet , Berihun Dachew

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引用次数: 0

Abstract

Background

The existing epidemiological evidence on the link between maternal depression and the risk of attention deficit and hyperactivity disorder (ADHD) symptoms in children lacks consistency. This systematic review and meta-analysis aimed to comprehensively synthesise the existing evidence on the relationship between maternal depression during the antenatal and postnatal periods and the risk of ADHD symptoms in offspring.

Methods

We systematically searched PubMed, Medline, Embase, Scopus, CINAHL, and PsychINFO to identify relevant articles. Random-effects meta-analysis models were employed to estimate the pooled odds ratio (OR) along with 95 % confidence intervals (CI). Statistical heterogeneity was assessed using Cochrane's Q-test and I2-test. Subgroup analysis was conducted to explore potential sources of variation within the included studies. Publication bias was assessed using a funnel plot and Egger’s test for regression asymmetry.

Results

Twenty-one observational studies, comprising 796,157 mother-offspring pairs, were included in the final analysis. Our meta-analysis found a 67 % (OR = 1.67, 95 % CI = 1.35–2.00) and a 53 % (OR = 1.53, 95 % CI = 1.27–1.78) increased risk of ADHD symptoms in the offspring of mothers experiencing antenatal and postnatal depression, respectively.

Conclusion

Our systematic review and meta-analysis identified an elevated risk of ADHD symptoms in the offspring of mothers who experienced both antenatal and postnatal depression. These findings underscore the importance of early screening and targeted intervention programs for at-risk children and adolescents.

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围产期抑郁症母亲的后代出现注意缺陷多动障碍症状的风险：系统回顾与荟萃分析

背景现有的流行病学证据表明，母亲抑郁与儿童出现注意力缺陷和多动症（ADHD）症状的风险之间缺乏一致性。本系统综述和荟萃分析旨在全面综合产前和产后母亲抑郁与后代ADHD症状风险之间关系的现有证据。方法我们系统地检索了PubMed、Medline、Embase、Scopus、CINAHL和PsychINFO，以确定相关文章。采用随机效应荟萃分析模型来估算汇总的几率比（OR）和 95 % 的置信区间（CI）。统计异质性采用 Cochrane 的 Q 检验和 I2 检验进行评估。进行了分组分析，以探索纳入研究中潜在的差异来源。采用漏斗图和 Egger 回归不对称检验对发表偏倚进行了评估。我们的荟萃分析发现，经历过产前和产后抑郁的母亲的后代出现多动症状的风险分别增加了 67% (OR = 1.67, 95 % CI = 1.35-2.00) 和 53% (OR = 1.53, 95 % CI = 1.27-1.78)。这些发现强调了早期筛查和针对高危儿童和青少年的干预计划的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian journal of psychiatry Medicine-Psychiatry and Mental Health

CiteScore

12.70

自引率

5.30%

发文量

297

审稿时长

35 days

期刊介绍： The Asian Journal of Psychiatry serves as a comprehensive resource for psychiatrists, mental health clinicians, neurologists, physicians, mental health students, and policymakers. Its goal is to facilitate the exchange of research findings and clinical practices between Asia and the global community. The journal focuses on psychiatric research relevant to Asia, covering preclinical, clinical, service system, and policy development topics. It also highlights the socio-cultural diversity of the region in relation to mental health.