Glucose oxidase: An emerging multidimensional treatment option for diabetic wound healing

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2024-10-15 DOI:10.1016/j.bioactmat.2024.10.006

Yuheng Liao , Zhenhe Zhang , Yanzhi Zhao , Shengming Zhang , Kangkang Zha, Lizhi Ouyang, Weixian Hu, Wu Zhou, Yun Sun, Guohui Liu

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引用次数: 0

Abstract

The healing of diabetic skin wounds is a complex process significantly affected by the hyperglycemic environment. In this context, glucose oxidase (GOx), by catalyzing glucose to produce gluconic acid and hydrogen peroxide, not only modulates the hyperglycemic microenvironment but also possesses antibacterial and oxygen-supplying functions, thereby demonstrating immense potential in the treatment of diabetic wounds. Despite the growing interest in GOx-based therapeutic strategies in recent years, a systematic summary and review of these efforts have been lacking. To address this gap, this review article outlines the advancements in the application of GOx and GOx-like nanozymes in the treatment of diabetic wounds, including reaction mechanisms, the selection of carrier materials, and synergistic therapeutic strategies such as multi-enzyme combinations, microneedle structures, and gas therapy. Finally, the article looks forward to the application prospects of GOx in aiding the healing of diabetic wounds and the challenges faced in translating these innovations to clinical practice. We sincerely hope that this review can provide readers with a comprehensive understanding of GOx-based diabetic treatment strategies, facilitate the rigorous construction of more robust multifunctional therapeutic systems, and ultimately benefit patients with diabetic wounds.

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葡萄糖氧化酶：糖尿病伤口愈合的新兴多维治疗方案

糖尿病皮肤伤口的愈合是一个复杂的过程，受到高血糖环境的严重影响。在这种情况下，葡萄糖氧化酶（GOx）通过催化葡萄糖产生葡萄糖酸和过氧化氢，不仅能调节高血糖微环境，还具有抗菌和供氧功能，因此在治疗糖尿病伤口方面具有巨大潜力。尽管近年来人们对基于 GOx 的治疗策略越来越感兴趣，但一直缺乏对这些工作的系统总结和回顾。针对这一空白，这篇综述文章概述了 GOx 和类 GOx 纳米酶在治疗糖尿病伤口方面的应用进展，包括反应机制、载体材料的选择，以及多酶组合、微针结构和气体疗法等协同治疗策略。最后，文章展望了 GOx 在帮助糖尿病伤口愈合方面的应用前景，以及将这些创新成果转化为临床实践所面临的挑战。我们衷心希望这篇综述能让读者对基于GOx的糖尿病治疗策略有一个全面的了解，促进严格构建更强大的多功能治疗系统，最终造福糖尿病伤口患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.