Maternal characteristics impact the relationship between fetal sex and superimposed preeclampsia

IF 2.5 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health Pub Date : 2024-10-15 DOI:10.1016/j.preghy.2024.101165

Akaninyene I. Noah , Camillia R. Comeaux , Ashley V. Hill , Maria J. Perez-Patron , Brandie DePaoli Taylor

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引用次数: 0

Abstract

Objectives

Associations between female fetal sex and preeclampsia occurring preterm have been reported but data is inconsistent across populations. We explored if the relationship between fetal sex and various hypertensive disorders of pregnancy (HDP) is modified by maternal characteristics.

Study design

We conducted a retrospective cohort study analyzing data from 43,737 singleton pregnancies. A modified Poisson regression model with robust error variance was used to calculate relative risk (RR) and 95% confidence intervals (CI) for the association between female fetal sex and HDP.

Main outcome measures

Models were adjusted for maternal age, smoking, body mass index, and gravidity. Relative excess risk due to interaction examined interaction between maternal characteristics and female fetal sex, on risk of HDP.

Results

Female fetal sex was marginally associated with superimposed preeclampsia (RR_adj. 1.13, 95 % confidence interval [CI] 1.00 – 1.28) but no other associations were observed. There was interaction between female fetal sex and advanced maternal age (>35 years), obesity, and parity. After stratifying by these variables, those with a female fetus and advanced maternal age had an increased risk of superimposed preeclampsia (RR_adj. 1.29, 95 %CI 1.05–1.58). We observed a similar trend among parous (RR_adj. 1.15, 95 %CI 1.00–1.34), foreign-born (RR_adj. 1.20, 95 %CI 1.00–1.44), and obese (RR_adj. 1.27, 95 %CI 1.03–1.35) individuals.

Conclusions

Female fetuses may respond differently to underlying maternal characteristics influencing risk of superimposed preeclampsia, but no other associations were observed.

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母体特征影响胎儿性别与叠加子痫前期之间的关系

目的有报道称女性胎儿性别与子痫前期和早产之间存在关联，但不同人群的数据并不一致。我们探讨了胎儿性别与各种妊娠高血压疾病（HDP）之间的关系是否会因母体特征而改变。研究设计我们进行了一项回顾性队列研究，分析了 43,737 例单胎妊娠的数据。主要结果测量模型根据产妇年龄、吸烟、体重指数和孕周进行调整。结果女性胎儿性别与叠加性子痫前期略有关联（RRadj.1.13，95% 置信区间 [CI] 1.00 - 1.28），但未观察到其他关联。女性胎儿的性别与高龄产妇（35 岁）、肥胖和胎次之间存在相互作用。根据这些变量进行分层后，胎儿性别为女性且高龄产妇发生叠加子痫前期的风险增加（RRadj.1.29，95 %CI 1.05-1.58）。我们在准妈妈（RRadj.1.15，95 %CI 1.00-1.34）、外国出生者（RRadj.1.20，95 %CI 1.00-1.44）和肥胖者（RRadj.1.27，95 %CI 1.03-1.35）中观察到类似的趋势。

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来源期刊

Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health OBSTETRICS & GYNECOLOGYPERIPHERAL VASCULAR-PERIPHERAL VASCULAR DISEASE

CiteScore

4.90

自引率

0.00%

发文量

127

期刊介绍： Pregnancy Hypertension: An International Journal of Women''s Cardiovascular Health aims to stimulate research in the field of hypertension in pregnancy, disseminate the useful results of such research, and advance education in the field. We publish articles pertaining to human and animal blood pressure during gestation, hypertension during gestation including physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy. The subtitle reflects the wider aspects of studying hypertension in pregnancy thus we also publish articles on in utero programming, nutrition, long term effects of hypertension in pregnancy on cardiovascular health and other research that helps our understanding of the etiology or consequences of hypertension in pregnancy. Case reports are not published unless of exceptional/outstanding importance to the field.