Unveiling the paradox: Infliximab-induced pustular psoriasis in psoriasis vulgaris

IF 0.3 4区 医学
K. Ferchichi , A. Chamli , R. Frioui , I. Helal , H. Hammami , A. Zaouak , S. Fenniche
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引用次数: 0

Abstract

Paradoxical psoriasis induced by tumor necrosis factor-alpha (TNF-α) antagonists is a rare adverse reaction of these drugs, with the pustular presentation being even more uncommon. Diagnosing and management of paradoxical pustular psoriasis in patients undergoing TNF-α antagonists treatment for psoriasis can be challenging. Therefore, we present a case report highlighting the occurrence of paradoxical pustular psoriasis caused by infliximab in a patient undergoing infliximab treatment for psoriasis, two weeks after the ninth injection. A switch to another TNF-α antagonist was considered, with no relapses at 6-month follow-up. This case underscores the importance of vigilant monitoring and recognition of atypical reactions and considering the switch to another TNF-α antagonist as a safe option for these patients.
揭开悖论的面纱:英夫利昔单抗诱发寻常型银屑病中的脓疱型银屑病
肿瘤坏死因子-α(TNF-α)拮抗剂诱发的矛盾性银屑病是这类药物的一种罕见不良反应,而脓疱型银屑病则更为罕见。在接受 TNF-α 拮抗剂治疗的银屑病患者中,诊断和处理矛盾性脓疱型银屑病具有挑战性。因此,我们提交了一份病例报告,着重介绍了一名接受英夫利昔单抗治疗的银屑病患者在注射第九次英夫利昔单抗两周后出现的由英夫利昔单抗引起的矛盾性脓疱型银屑病。考虑改用另一种 TNF-α 拮抗剂后,随访 6 个月未再复发。该病例强调了对非典型反应进行警惕性监测和识别的重要性,并考虑将换用另一种TNF-α拮抗剂作为这些患者的安全选择。
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来源期刊
Revue Francaise d Allergologie
Revue Francaise d Allergologie Medicine-Immunology and Allergy
自引率
33.30%
发文量
349
期刊介绍: La Revue Française d''Allergologie : un véritable forum pour faire connaître des travaux originaux et permettre la diffusion de l''information auprès de toutes les spécialités concernées par les pathologies allergiques. La Revue Française d''Allergologie (8 numéros par an) est au carrefour de nombreuses spécialités - dermatologie, pédiatrie, ORL, pneumologie, ophtalmologie, médecine interne - qui, toutes, ont à traiter des maladies allergiques. Les symptômes des allergies fondés sur des mécanismes communs sont le plus souvent associés et se succèdent chez un même patient. En forte progression depuis 20 ans, les maladies allergiques sont dans l''attente de perfectionnements et d''avancées thérapeutiques qui permettront aux nombreux patients qui en sont atteints de mieux vivre avec leurs allergies. La Revue Française d''Allergologie se veut donc un véritable forum de discussions et d''échanges entre tous les spécialistes confrontés aux pathologies
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