Olfactory bulb stimulation mitigates Alzheimer's-like disease progression

IF 4.8 1区医学 Q1 NEUROSCIENCES

CNS Neuroscience & Therapeutics Pub Date : 2024-10-15 DOI:10.1111/cns.70056

Morteza Salimi, Milad Nazari, Payam Shahsavar, Samaneh Dehghan, Mohammad Javan, Javad Mirnajafi-Zadeh, Mohammad Reza Raoufy

{"title":"Olfactory bulb stimulation mitigates Alzheimer's-like disease progression","authors":"Morteza Salimi, Milad Nazari, Payam Shahsavar, Samaneh Dehghan, Mohammad Javan, Javad Mirnajafi-Zadeh, Mohammad Reza Raoufy","doi":"10.1111/cns.70056","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Deep brain stimulation (DBS) has demonstrated potential in mitigating Alzheimer's disease (AD). However, the invasive nature of DBS presents challenges for its application. The olfactory bulb (OB), showing early AD-related changes and extensive connections with memory regions, offers an attractive entry point for intervention, potentially restoring normal activity in deteriorating memory circuits.</p>\n </section>\n \n <section>\n \n <h3> Aims</h3>\n \n <p>Our study examined the impact of electrically stimulating the OB on working memory as well as pathological and electrophysiological alterations in the OB, medial prefrontal cortex, hippocampus, and entorhinal cortex in amyloid beta (Aβ) AD model rats.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Male Wistar rats underwent surgery for electrode implantation in brain regions, inducing Alzheimer's-like disease. Bilateral olfactory bulb (OB) electrical stimulation was performed for 1 hour daily to the OB of stimulation group animals for 18 consecutive days, followed by the evaluations of histological, behavioral, and local field potential signal processing.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>OB stimulation counteracted Aβ plaque accumulation and prevented AD-induced working memory impairments. Furthermore, it prompted an increase in power across diverse frequency bands and enhanced functional connectivity, particularly in the gamma band, within the investigated regions during a working memory task.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>This preclinical investigation highlights the potential of olfactory pathway-based brain stimulation to modulate the activity of deep-seated memory networks for AD treatment. Importantly, the accessibility of this pathway via the nasal cavity lays the groundwork for the development of minimally invasive approaches targeting the olfactory pathway for brain modulation.</p>\n </section>\n </div>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"30 10","pages":""},"PeriodicalIF":4.8000,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70056","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"CNS Neuroscience & Therapeutics","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/cns.70056","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Deep brain stimulation (DBS) has demonstrated potential in mitigating Alzheimer's disease (AD). However, the invasive nature of DBS presents challenges for its application. The olfactory bulb (OB), showing early AD-related changes and extensive connections with memory regions, offers an attractive entry point for intervention, potentially restoring normal activity in deteriorating memory circuits.

Aims

Our study examined the impact of electrically stimulating the OB on working memory as well as pathological and electrophysiological alterations in the OB, medial prefrontal cortex, hippocampus, and entorhinal cortex in amyloid beta (Aβ) AD model rats.

Methods

Male Wistar rats underwent surgery for electrode implantation in brain regions, inducing Alzheimer's-like disease. Bilateral olfactory bulb (OB) electrical stimulation was performed for 1 hour daily to the OB of stimulation group animals for 18 consecutive days, followed by the evaluations of histological, behavioral, and local field potential signal processing.

Results

OB stimulation counteracted Aβ plaque accumulation and prevented AD-induced working memory impairments. Furthermore, it prompted an increase in power across diverse frequency bands and enhanced functional connectivity, particularly in the gamma band, within the investigated regions during a working memory task.

Conclusion

This preclinical investigation highlights the potential of olfactory pathway-based brain stimulation to modulate the activity of deep-seated memory networks for AD treatment. Importantly, the accessibility of this pathway via the nasal cavity lays the groundwork for the development of minimally invasive approaches targeting the olfactory pathway for brain modulation.

Abstract Image

查看原文本刊更多论文

刺激嗅球可减轻阿尔茨海默氏症样疾病的进展

背景大脑深部刺激（DBS）已被证明在缓解阿尔茨海默病（AD）方面具有潜力。然而，DBS 的侵入性为其应用带来了挑战。嗅球（OB）显示出与阿兹海默症相关的早期变化，并与记忆区域有广泛联系，为干预提供了一个有吸引力的切入点，有可能恢复恶化的记忆回路的正常活动。目的我们的研究考察了电刺激 OB 对淀粉样β（Aβ）AD 模型大鼠工作记忆的影响，以及 OB、内侧前额叶皮层、海马和内黑质的病理和电生理改变。方法雄性 Wistar 大鼠接受手术，在脑区植入电极，诱发类似阿尔茨海默病的疾病。对刺激组大鼠的双侧嗅球（OB）进行连续18天、每天1小时的电刺激，然后进行组织学、行为学和局部场电位信号处理评估。结果刺激外鼻刺激可抑制Aβ斑块的积累，并防止AD引起的工作记忆障碍。此外，在完成工作记忆任务时，它还能提高不同频段的功率，增强研究区域内的功能连接，尤其是伽马频段。结论这项临床前研究强调了基于嗅觉通路的脑刺激在调节深层记忆网络活动以治疗老年痴呆症方面的潜力。重要的是，通过鼻腔进入这一通路为开发针对嗅觉通路的微创方法奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.