Biodegradable Temporising matrix in the reconstruction of complex wounds: A systematic review and meta-analysis

IF 2.6 3区医学 Q2 DERMATOLOGY

International Wound Journal Pub Date : 2024-10-14 DOI:10.1111/iwj.70025

George Lane, Niall James Fitzpatrick, Olga Kastritsi, Georgios Matzakanis, Fatima Braimah, Mohamad Nazmi M. Nordin, Ayobami Asaju, Fouad Tariq Aziz, Shafiq Rahman, Rebecca Rollett

{"title":"Biodegradable Temporising matrix in the reconstruction of complex wounds: A systematic review and meta-analysis","authors":"George Lane, Niall James Fitzpatrick, Olga Kastritsi, Georgios Matzakanis, Fatima Braimah, Mohamad Nazmi M. Nordin, Ayobami Asaju, Fouad Tariq Aziz, Shafiq Rahman, Rebecca Rollett","doi":"10.1111/iwj.70025","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>To assess the efficacy of biodegradable temporising matrix (BTM) in complex wound reconstruction.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The authors conducted a systematic review and meta-analysis as per the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines following a literature search assessing BTM in complex wound reconstruction. The primary outcome measures included the proportion of BTM integration as well as integration time. Secondary outcomes included graft take over BTM, infection rate and other complications as well as scar outcome.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Twenty six studies met the inclusion criteria with a total of 1153 complex wounds. The mean proportional integration was 92.7% at (95% confidence intervals [CI] 88.57, 96.87, <i>p</i> < 0.001) with a mean integration time of 34.05 days (95% CI 33.33, 34.79, <i>p</i> < 0.001). The infection rate was low at 12.6% with an untransformed proportion metric assessment (0.126, 0.08–0.168, <i>p</i> < 0.001) at the site of BTM application. Favourable scar outcomes were reported using the matching assessment using photographs with scars (MAPS) and patient and observer scar assessment scales (POSAS).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>BTM offers a robust dermal template in reconstruction of complex wounds. The authors recommend for randomised controlled trials to enhance the current evidence base.</p>\n </section>\n </div>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"21 10","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70025","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Wound Journal","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/iwj.70025","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

To assess the efficacy of biodegradable temporising matrix (BTM) in complex wound reconstruction.

Methods

The authors conducted a systematic review and meta-analysis as per the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines following a literature search assessing BTM in complex wound reconstruction. The primary outcome measures included the proportion of BTM integration as well as integration time. Secondary outcomes included graft take over BTM, infection rate and other complications as well as scar outcome.

Results

Twenty six studies met the inclusion criteria with a total of 1153 complex wounds. The mean proportional integration was 92.7% at (95% confidence intervals [CI] 88.57, 96.87, p < 0.001) with a mean integration time of 34.05 days (95% CI 33.33, 34.79, p < 0.001). The infection rate was low at 12.6% with an untransformed proportion metric assessment (0.126, 0.08–0.168, p < 0.001) at the site of BTM application. Favourable scar outcomes were reported using the matching assessment using photographs with scars (MAPS) and patient and observer scar assessment scales (POSAS).

Conclusion

BTM offers a robust dermal template in reconstruction of complex wounds. The authors recommend for randomised controlled trials to enhance the current evidence base.

查看原文本刊更多论文

用于复杂伤口重建的生物可降解临时基质：系统回顾与荟萃分析

目的评估生物可降解临时基质（BTM）在复杂伤口重建中的疗效。方法作者根据系统综述和荟萃分析首选报告项目（PRISMA）指南进行了系统综述和荟萃分析，并对复杂伤口重建中的 BTM 进行了文献检索。主要结果指标包括 BTM 融合比例和融合时间。次要结果包括移植物对 BTM 的吸收、感染率和其他并发症以及疤痕结果。结果符合纳入标准的研究有 26 项，共涉及 1153 个复杂伤口。平均整合比例为 92.7%（95% 置信区间 [CI] 88.57, 96.87, p <0.001），平均整合时间为 34.05 天（95% 置信区间 33.33, 34.79, p <0.001）。BTM 应用部位的感染率较低，仅为 12.6%，未转化比例评估值为 (0.126, 0.08-0.168, p <0.001)。使用疤痕照片配对评估（MAPS）以及患者和观察者疤痕评估量表（POSAS）均报告了良好的疤痕效果。结论 BTM 为复杂伤口的重建提供了强大的真皮模板。作者建议进行随机对照试验，以加强现有的证据基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Wound Journal DERMATOLOGY-SURGERY

CiteScore

4.50

自引率

12.90%

发文量

266

审稿时长

6-12 weeks

期刊介绍： The Editors welcome papers on all aspects of prevention and treatment of wounds and associated conditions in the fields of surgery, dermatology, oncology, nursing, radiotherapy, physical therapy, occupational therapy and podiatry. The Journal accepts papers in the following categories: - Research papers - Review articles - Clinical studies - Letters - News and Views: international perspectives, education initiatives, guidelines and different activities of groups and societies. Calendar of events The Editors are supported by a board of international experts and a panel of reviewers across a range of disciplines and specialties which ensures only the most current and relevant research is published.