Physical activity modifies the association between atherogenic index of plasma and prediabetes and diabetes: A cross-sectional analysis

IF 3 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Pub Date : 2024-10-13 DOI:10.1111/1753-0407.70006

Shenglan Yang, Xinyu Gou, Hui Dong, Limei Chen, Yiyan Wang, Jing Wu

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Abstract

Background

Although research has explored the association between atherogenic index of plasma (AIP) and prediabetes and diabetes, there is still not sufficient available evidence the role of physical activity (PA) in this relationship. Our purpose is to examine the complex connections between AIP, PA, and prediabetes and diabetes in a young and middle-aged population.

Methods

This study included 2220 individuals from the general population, aged 20–60 years. AIP was calculated from the logarithm of the triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio. PA was assessed depending to the American Heart Association (AHA) criteria and categorized into medium-high and low PA levels. We used binary logistic regression to explore associations and subsequently performed sensitivity and subgroup analyses.

Results

The 2220 participants had a mean age of 38 years, with a mean AIP of −0.1185, and a prediabetes and diabetes prevalence of 7.2%. After adjusting for auxiliary variables, AIP was positively correlated with prediabetes and diabetes (odds ratio [OR]: 3.447, 95% confidence interval [CI]: 1.829–6.497). In the low PA population, the prevalence of prediabetes and diabetes raised significantly with higher AIP (OR: 3.678, 95% CI: 1.819–7.434). This association was not meaningful in the medium to high PA population (OR: 1.925, 95% CI: 0.411–9.007). Joint and sensitivity analyze results also showed agreement. Restricted cubic spline identified a linear relationship between AIP and the prevalence of prediabetes and diabetes. Notably, the prevalence significantly increases when AIP values exceed −0.16 (p for linearity <0.05). The findings revealed heterogeneity across subgroups stratified by sex and age.

Conclusions

PA may modify the link as regards AIP with prediabetes and diabetes in young and middle-aged populations. Adherence to PA prevents the adverse effects of abnormal glucose metabolism caused by dyslipidemia, particularly in women.

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体育锻炼可改变血浆致动脉粥样硬化指数与糖尿病前期和糖尿病之间的关系：横断面分析

背景虽然已有研究探讨了血浆致动脉粥样硬化指数（AIP）与糖尿病前期和糖尿病之间的关系，但仍没有足够的证据表明体力活动（PA）在这一关系中的作用。我们的目的是在中青年人群中研究 AIP、PA 与糖尿病前期和糖尿病之间的复杂关系。方法这项研究包括 2220 名 20-60 岁的普通人群。AIP根据甘油三酯（TG）与高密度脂蛋白胆固醇（HDL-C）比率的对数计算。活动量根据美国心脏协会（AHA）的标准进行评估，并分为中高和低活动量水平。我们使用二元逻辑回归来探讨相关性，随后进行了敏感性和亚组分析。结果 2220 名参与者的平均年龄为 38 岁，平均 AIP 为-0.1185，糖尿病前期和糖尿病患病率为 7.2%。对辅助变量进行调整后，AIP 与糖尿病前期和糖尿病呈正相关（比值比 [OR]：3.447，95% 置信区间 [CI]：1.829-6.497）。在低 PA人群中，糖尿病前期和糖尿病的患病率随着 AIP 的增加而显著上升（OR：3.678，95% 置信区间：1.819-7.434）。而在中高运动量人群中，这种关联并不明显（OR：1.925，95% CI：0.411-9.007）。联合分析和敏感性分析结果也显示出一致性。限制立方样条曲线确定了 AIP 与糖尿病前期和糖尿病患病率之间的线性关系。值得注意的是，当 AIP 值超过-0.16 时，患病率会明显增加（线性相关系数为 0.05）。研究结果显示，按性别和年龄划分的亚组之间存在异质性。结论在中青年人群中，PA 可改变 AIP 与糖尿病前期和糖尿病之间的联系。坚持体育锻炼可防止血脂异常引起的糖代谢异常的不良影响，尤其是对女性而言。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

2.20%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.