Green synthesis of cerium oxide nanoparticles via Linum usitatissimum seeds extract and assessment of its biological effects

IF 1.5 4区材料科学 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY

Micro & Nano Letters Pub Date : 2024-10-13 DOI:10.1049/mna2.70003

Zahra Foroutan, Zahra Sabouri, Amir Reza Afshari, Asma Mostafapour, Bahareh Farasati Far, Mohammad Jalili-Nik, Majid Darroudi

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Abstract

In the current work, CeO₂-NPs were produced via a green chemistry process via Linum usitatissimum seeds extract as the stabilizing agent. The CeO₂-NPs were characterized by the results of analytical techniques such as TGA/DTA, FTIR, UV–vis, XPS, XRD, and FESEM/PSA/EDX. The outcomes of the XRD pattern affirmed the crystalline structure of this product with the suggested size of about 20 nm, while the FESEM/PSA pictures presented spherical morphology. Additionally, the XPS analysis of CeO₂-NPs affirmed the presence of a Ce⁺³ oxidation state in the sample, as well as Ce⁺⁴ as the major valence of cerium oxide. The results of the MTT test on Huh-7 cancer cells and HFF normal cells displayed the lack of any significant cytotoxicity even at concentrations up to 1000 µg/mL. Therefore, the obtained synthesized CeO₂-NPs through this green method could be suggested as a prospective agent for medical applications due to its non-toxic effects.

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通过亚麻籽提取物绿色合成氧化铈纳米粒子并评估其生物效应

在当前的研究中，通过绿色化学工艺，以亚麻籽提取物作为稳定剂，制备了 CeO2-NPs。通过 TGA/DTA、FTIR、UV-vis、XPS、XRD 和 FESEM/PSA/EDX 等分析技术对 CeO2-NPs 进行了表征。XRD 图谱结果证实了该产品的结晶结构，建议尺寸约为 20 纳米，而 FESEM/PSA 图片则显示了球形形态。此外，CeO2-NPs 的 XPS 分析表明，样品中存在 Ce+3 氧化态，Ce+4 是氧化铈的主要价态。对 Huh-7 癌细胞和 HFF 正常细胞进行的 MTT 测试结果表明，即使浓度高达 1000 µg/mL，也没有明显的细胞毒性。因此，通过这种绿色方法合成的 CeO2-NPs 因其无毒作用，可作为医疗应用的前瞻性制剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Micro & Nano Letters 工程技术-材料科学：综合

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

2.8 months

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