Chemsex and rising substance use linked to sexually transmitted infections among men who have sex with men living with HIV in Bangkok, Thailand

IF 1.5 Q4 INFECTIOUS DISEASES

IJID regions Pub Date : 2024-09-28 DOI:10.1016/j.ijregi.2024.100465

Camilla Muccini , Suteeraporn Pinyakorn , Christy Kolsteeg , Eugène Kroon , Carlo Sacdalan , Trevor A. Crowell , Phillip Chan , Robert Paul , Denise Hsu , Nittaya Phanuphak , Donn J. Colby , RV254/SEARCH010 Study Group

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Abstract

Objectives

We report longitudinal trends in alcohol and recreational drug use, and their associations with sexual behaviors and clinical outcomes in a Thai cohort of predominantly men who have sex with men (MSM) living with HIV.

Methods

From 2017 to 2019, participants in the RV254/SEARCH010 acute HIV cohort answered questions every 24 weeks about drug use and sexual behaviors. Longitudinal trends were assessed using the χ2 test for trend. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for factors potentially associated with recreational drug and alcohol use.

Results

Among 604 participants, the median age was 26 (interquartile range 23-31) years, and 93.5% were MSM. Alcohol consumption was reported in 83.3% and recreational drug use in 46.9% during the study period, with rising trends in both over the years. Participants who reported recreational drug use were more likely to have hepatitis C (OR 3.42, 95% CI 1.88-6.21), syphilis (OR 2.69, 1.75-4.13), gonorrhea (OR 7.74, 5.04-11.89), and chlamydia (OR 1.61, 1.12-2.31), and to engage in group sex (OR 7.74, 5.04-11.89). Participants who used any recreational drugs had more frequent viral blips (23.1% vs 14.2%, P = 0.007) and reported missed doses of antiretroviral drugs more often (52.4% vs 36.9%, P <0.001), but had no significant difference in viral suppression (94.1% vs 97.4%, P = 0.06).

Conclusions

Among MSM living with HIV in Bangkok, recreational drug use has increased in recent years and was associated with hepatitis C and sexually transmitted infections, especially among men who participate in group sex. Prevention strategies and other interventions may improve treatment adherence and other HIV outcomes.

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泰国曼谷感染艾滋病毒的男男性行为者中，化学性性行为和药物使用增加与性传播感染有关

目的我们报告了一个主要由男男性行为者（MSM）组成的泰国 HIV 感染者队列中酒精和娱乐性药物使用的纵向趋势及其与性行为和临床结果的关联。方法从 2017 年到 2019 年，RV254/SEARCH010 急性 HIV 队列的参与者每 24 周回答一次有关药物使用和性行为的问题。采用χ2趋势检验评估纵向趋势。采用逻辑回归法估算与娱乐性吸毒和酗酒可能相关的因素的几率比（ORs）和 95% 的置信区间（CIs）。结果在 604 名参与者中，年龄中位数为 26 岁（四分位数范围为 23-31 岁），93.5% 为 MSM。在研究期间，83.3%的参与者报告了饮酒情况，46.9%的参与者报告了使用娱乐性药物的情况，而且这两种情况都呈逐年上升趋势。报告使用娱乐性药物的参与者更有可能患有丙型肝炎（OR 3.42，95% CI 1.88-6.21）、梅毒（OR 2.69，1.75-4.13）、淋病（OR 7.74，5.04-11.89）和衣原体（OR 1.61，1.12-2.31），并且更有可能进行群交（OR 7.74，5.04-11.89）。使用任何娱乐性药物的参与者更频繁地出现病毒突变（23.1% vs 14.2%，P = 0.007），更频繁地报告错过抗逆转录病毒药物剂量（52.4% vs 36.9%，P <0.001），但在病毒抑制方面没有显著差异（94.1% vs 97.4%，P <0.001）。结论在曼谷感染艾滋病毒的男男性行为者中，娱乐性吸毒近年来有所增加，并与丙型肝炎和性传播感染有关，尤其是在参与群交的男性中。预防策略和其他干预措施可改善治疗依从性和其他艾滋病结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IJID regions Infectious Diseases

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

64 days