Preliminary study of a compact epithermal neutron absolute flux intensity measurement system for real-time in-vivo dose monitoring in boron neutron capture therapy

IF 1.6 3区物理与天体物理 Q2 NUCLEAR SCIENCE & TECHNOLOGY

Radiation Measurements Pub Date : 2024-10-10 DOI:10.1016/j.radmeas.2024.107308

Jiye Qiu , Daisuke Hatano , Yulin Ge , Nikolaos Voulgaris , Kohei Sagara , Zhaopeng Qiao , Shingo Tamaki , Sachie Kusaka , Takushi Takata , Isao Murata

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引用次数: 0

Abstract

Boron neutron capture therapy (BNCT) is a radiotherapy technology that selectively kills tumor cells via the ¹⁰B(n, α)⁷Li reactions. Epithermal neutrons (0.5 eV–10 keV) are emitted and converted into thermal neutrons, which have a larger neutron capture reaction cross-section, by slowing down in the human body before reaching the tumor. Recently, the development of an epithermal neutron absolute flux intensity measurement technique has become crucial for real-time in-vivo dose monitoring in BNCT. In this study, a concept for a measurement system consisting of multiple compact scintillator with optical fibers detectors covered with neutron absorbers of various thicknesses is proposed. The designed system achieves a consistent response to epithermal neutrons with a theoretical coefficient of variation not higher than 5% for both LiCAF and EJ-254 scintillators. The theoretical feasibility of the proposed measurement system was investigated by an irradiation experiment carried out at the heavy water neutron irradiation facility at the Kyoto University Reactor. The experimental results indicated that further improvement and refinement are necessary to meet the high accuracy and precision required for real-time dose monitoring in clinical applications.

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用于硼中子俘获疗法中实时体内剂量监测的紧凑型外延中子绝对通量强度测量系统的初步研究

硼中子俘获疗法（BNCT）是一种通过10B(n, α)7Li反应选择性杀死肿瘤细胞的放射治疗技术。表层中子（0.5 eV-10 keV）在到达肿瘤之前，会在人体内减速并转化为热中子，后者具有更大的中子俘获反应截面。近来，表皮中子绝对通量强度测量技术的发展已成为 BNCT 实时体内剂量监测的关键。本研究提出了一种测量系统概念，该系统由多个紧凑型闪烁体和光纤探测器组成，探测器上覆盖有不同厚度的中子吸收体。所设计的系统对表热中子的响应一致，LiCAF 和 EJ-254 闪烁器的理论变异系数均不高于 5%。在京都大学反应堆重水中子辐照设施进行的辐照实验研究了所提测量系统的理论可行性。实验结果表明，要达到临床应用中实时剂量监测所需的高准确度和精确度，还需要进一步改进和完善。

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来源期刊

Radiation Measurements 工程技术-核科学技术

CiteScore

4.10

自引率

20.00%

发文量

116

审稿时长

48 days

期刊介绍： The journal seeks to publish papers that present advances in the following areas: spontaneous and stimulated luminescence (including scintillating materials, thermoluminescence, and optically stimulated luminescence); electron spin resonance of natural and synthetic materials; the physics, design and performance of radiation measurements (including computational modelling such as electronic transport simulations); the novel basic aspects of radiation measurement in medical physics. Studies of energy-transfer phenomena, track physics and microdosimetry are also of interest to the journal. Applications relevant to the journal, particularly where they present novel detection techniques, novel analytical approaches or novel materials, include: personal dosimetry (including dosimetric quantities, active/electronic and passive monitoring techniques for photon, neutron and charged-particle exposures); environmental dosimetry (including methodological advances and predictive models related to radon, but generally excluding local survey results of radon where the main aim is to establish the radiation risk to populations); cosmic and high-energy radiation measurements (including dosimetry, space radiation effects, and single event upsets); dosimetry-based archaeological and Quaternary dating; dosimetry-based approaches to thermochronometry; accident and retrospective dosimetry (including activation detectors), and dosimetry and measurements related to medical applications.