Micelles as nanocarriers of fluorescent and magnetic dendrimers for potential bimodal imaging applications

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments Pub Date : 2024-10-09 DOI:10.1016/j.dyepig.2024.112482

Yufei Wu , Vega Lloveras , Songbai Zhang , Juan Tolosa , Joaquín C. García-Martínez , José Vidal-Gancedo

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Abstract

Bimodal magnetic-fluorescent materials that integrate magnetic and fluorescent properties have attracted significant attention due to their potential applications in biomedical imaging, biosensing, and therapeutic diagnosis. Tetra-amido-TEMPO 1, a compound that combines a fluorescent oligo (styryl)benzene dendrimer core with TEMPO radicals in its four branches was synthesized and used to form micelles with CTAB in water. DLS and Cryo-TEM techniques revealed the formation of micelles exhibiting a narrow particle size distribution, with an average hydrodynamic diameter ranging from 95 to 140 nm. After micellization, the ultraviolet–visible absorption and fluorescence emission intensities of micelles increased with tetra-amido-TEMPO concentration and EPR spectroscopy demonstrated consistent three-line spectra in the micelles, with the integrated area directly proportional to the amount of tetra-amido-TEMPO present. Besides, sufficient contrast enhancement in the proton T₁ relaxation time-weighted magnetic resonance images in vitro proved their ability to act as magnetic resonance imaging (MRI) contrast agents. These tetra-amido-TEMPO/CTAB micelles offer an aqueous-compatible system for this bimodal fluorescent-magnetic molecule, showcasing proof of concept of their potential for biomedical applications.

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作为荧光和磁性树枝状聚合物纳米载体的胶束，具有潜在的双模成像应用价值

融合了磁性和荧光特性的双模磁性荧光材料因其在生物医学成像、生物传感和治疗诊断方面的潜在应用而备受关注。四酰胺-TEMPO 1 是一种将荧光寡（苯乙烯基）苯树枝状聚合物核心与 TEMPO 自由基的四个分支结合在一起的化合物。DLS 和 Cryo-TEM 技术显示，形成的胶束粒径分布较窄，平均流体力学直径在 95 到 140 nm 之间。胶束化后，胶束的紫外可见吸收和荧光发射强度随四氨基-TEMPO 浓度的增加而增加，EPR 光谱显示胶束中存在一致的三线光谱，其积分面积与四氨基-TEMPO 的含量成正比。此外，体外质子 T1 驰豫时间加权磁共振图像的充分对比增强也证明了它们作为磁共振成像（MRI）造影剂的能力。这些四脒基 TEMPO/CTAB 胶束为这种双模荧光磁性分子提供了一种水相兼容的体系，证明了它们在生物医学应用方面的潜力。

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.