Supplemental ambient lighting intervention to improve sleep in Parkinson's disease: A pilot trial

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders Pub Date : 2024-09-20 DOI:10.1016/j.parkreldis.2024.107149

Andrea S. Yoo , Adina Wise , Roberto A. Ortega , Deborah Raymond , Barbara Plitnick , Jennifer Brons , Judy Liang , Susan B. Bressman , Mengxi Yang , David Pedler , Mariana G. Figueiro , Rachel Saunders-Pullman

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引用次数: 0

Abstract

Importance

Sleep disturbances in Parkinson's disease (PD) are common and often adversely affect quality of life. Light therapy has benefited sleep quality and mood outcomes in various populations but results to date with conventional light therapy boxes in PD patients have been mixed. We hypothesized that a passive lighting intervention, applied in the morning and designed to maximally affect the circadian system, would improve measures of sleep and mood in PD patients.

Methods

In this single-arm, within-subjects intervention study, baseline objective sleep (actigraphy), subjective sleep quality (questionnaires), and subjective mood (questionnaires) data were collected for 1 week. Lighting was then administered to participants via table/floor lamps installed in the home or via personal light therapy glasses for 2 h in the morning, 7 days per week, over the following 4-week period. Post-intervention data for the same outcomes were collected during the final week of the intervention period.

Results

Among 20 participants (12 women, 8 men; mean [SD] age 72.1 [9.5] years, disease duration 9.0 [5.2] years), objective sleep duration increased significantly by 28.5 min (p = 0.029) and objective sleep time increased significantly by 19.9 min (p = 0.026).

Conclusion

Passive and easily administered lighting interventions for improving sleep in PD patients hold promise as a treatment for mitigating symptoms and improving quality of life in PD.

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补充环境照明干预，改善帕金森病患者的睡眠：试点试验

重要性帕金森病（PD）患者的睡眠障碍很常见，通常会对生活质量产生不利影响。光疗对不同人群的睡眠质量和情绪都有益处，但迄今为止，帕金森病患者使用传统光疗箱的结果却不尽相同。我们假设，在早晨进行被动照明干预，旨在最大限度地影响昼夜节律系统，将改善帕金森病患者的睡眠和情绪。方法在这项单臂、受试者内干预研究中，我们收集了为期一周的基线客观睡眠（动图）、主观睡眠质量（问卷）和主观情绪（问卷）数据。然后，在接下来的 4 周内，通过安装在家中的台灯/落地灯或个人光疗眼镜为参与者提供每周 7 天、每天早上 2 小时的照明。结果在 20 名参与者（12 名女性，8 名男性；平均 [SD] 年龄 72.1 [9.5] 岁，病程 9.0 [5.2] 年）中，客观睡眠时间显著增加了 28.结果20 名参与者（12 名女性，8 名男性；平均 [SD] 年龄 72.1 [9.5] 岁；病程 9.0 [5.2] 年）中，客观睡眠时间显著增加了 28.5 分钟（p = 0.029），客观睡眠时间显著增加了 19.9 分钟（p = 0.026）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Parkinsonism & related disorders 医学-临床神经学

CiteScore

6.20

自引率

4.90%

发文量

292

审稿时长

39 days

期刊介绍： Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.