Sarcopenia as a predictive factor for febrile neutropenia during induction chemotherapy in head and neck squamous cell cancer

IF 1.6 4区医学 Q2 OTORHINOLARYNGOLOGY

Auris Nasus Larynx Pub Date : 2024-10-13 DOI:10.1016/j.anl.2024.09.010

Ken Kasahara , Seiji Shigetomi , Yoichiro Sato , Yorihisa Imanishi , Yuichi Ikari , Takanori Nishiyama , Yuki Matsui , Seiichi Shinden , Hiroyuki Ozawa , Takeyuki Kono

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引用次数: 0

Abstract

Objective

Febrile neutropenia (FN) is the most serious toxicity in patients with head and neck squamous cell carcinoma (HNSCC) treated with induction chemotherapy (IC). Although it is well-known that sarcopenia is a risk factor for severe toxicity of (chemo)radiotherapy, the data on the association between sarcopenia and FN during IC in HNSCC patients is rare. This study determined the impact of sarcopenia on FN during IC.

Methods

IC-treated patients with HNSCC were enrolled in this study. Skeletal muscle mass (SMM) at the C3 vertebral body was used to define sarcopenia from computed tomography (CT) scans. To determine the predictive effect of low SMM on FN, logistic regression analysis was performed.

Results

In this study, 71 patients were included, of whom 28 had low SMM and 14 experienced FN. In multivariate analysis, low SMM and high CRP were the independent predictive factors for FN. The combination index of sarcopenia and CRP showed a greater odds ratio than sarcopenia alone suggesting a more significant predicting indicator.

Conclusions

Sarcopenia defined by CT imaging is associated with FN in patients with HNSCC treated with IC. The combination of sarcopenia and high CRP is a more significant risk factor, and it helps determine patients at risk of FN during IC.

查看原文本刊更多论文

肉骨减少症是头颈部鳞状细胞癌诱导化疗期间发热性中性粒细胞减少症的一个预测因素

目的发热性中性粒细胞减少症（FN）是头颈部鳞状细胞癌（HNSCC）患者接受诱导化疗（IC）时最严重的毒性反应。尽管众所周知，肌肉疏松症是导致（化）放疗严重毒性的危险因素，但有关 HNSCC 患者在诱导化疗期间肌肉疏松症与 FN 之间关系的数据却非常罕见。本研究确定了肌肉疏松症对 IC 期间 FN 的影响。C3椎体处的骨骼肌质量（SMM）是通过计算机断层扫描（CT）来定义肌肉疏松症的。为了确定低 SMM 对 FN 的预测作用，研究人员进行了逻辑回归分析。在多变量分析中，低 SMM 和高 CRP 是 FN 的独立预测因素。与单纯的肌肉疏松症相比，肌肉疏松症和 CRP 的组合指数显示出更大的几率，这表明这是一个更重要的预测指标。肌肉疏松症与高 CRP 的组合是一个更重要的风险因素，有助于确定接受 IC 治疗的患者是否有发生 FN 的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Auris Nasus Larynx 医学-耳鼻喉科学

CiteScore

3.40

自引率

5.90%

发文量

169

审稿时长

30 days

期刊介绍： The international journal Auris Nasus Larynx provides the opportunity for rapid, carefully reviewed publications concerning the fundamental and clinical aspects of otorhinolaryngology and related fields. This includes otology, neurotology, bronchoesophagology, laryngology, rhinology, allergology, head and neck medicine and oncologic surgery, maxillofacial and plastic surgery, audiology, speech science. Original papers, short communications and original case reports can be submitted. Reviews on recent developments are invited regularly and Letters to the Editor commenting on papers or any aspect of Auris Nasus Larynx are welcomed. Founded in 1973 and previously published by the Society for Promotion of International Otorhinolaryngology, the journal is now the official English-language journal of the Oto-Rhino-Laryngological Society of Japan, Inc. The aim of its new international Editorial Board is to make Auris Nasus Larynx an international forum for high quality research and clinical sciences.