Pharmacological potential of Curcuma longa endophytes

The Microbe Pub Date : 2024-10-09 DOI:10.1016/j.microb.2024.100187

Garima Sharma , Surbhi Agarwal , Rashmi Bhardwaj , Vitthal T. Barvkar , Rucha C. Godbole , Vinay Kumar , Nandita Narayanasamy , Vartika Mathur

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Abstract

Endophytes contribute to plant fitness and defence by producing bioactive secondary metabolites, which may be utilized in various industrial applications. We assessed the potential of bioactive compounds from the endophytes of Curcuma longa for therapeutic properties. We screened phytochemicals obtained from the C. longa endophytes for host-specific bioactive compounds which were also evaluated for their antimicrobial, anti-inflammatory and antioxidant potential. 59 endophytes were isolated from leaves and rhizome of C. longa, among which isolates Fusarium fujikuroi PCLCUT2 and Bacillus pacificus NCLALC2 showed significant antioxidant and anti-inflammatory properties. PCLCUT2 showed strong antioxidant potential (IC₅₀ 1.33 mg/mL) and the presence of compounds such as (-)-epicatechin and curcumin. B. pacificus NCLALC2 exhibited strong anti-inflammatory and antimicrobial potential (MIC 200 µg/L) against Mycobacterium smegmatis. NCLALC2 showed the presence of 12 potential bioactive compounds including Calicoferol D, terpinolene and alpha-phellandrene. With the presence of host-specific compounds, the two endophytes hold promising potential as cost-effective sources of bioactive metabolites for pharmacological applications.

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姜黄内生菌的药理潜力

内生菌通过产生具有生物活性的次生代谢物来提高植物的适应能力和防御能力，这些次生代谢物可用于各种工业用途。我们评估了莪术内生菌中生物活性化合物的治疗潜力。我们筛选了从莪术内生菌中获得的植物化学物质，以寻找宿主特异性生物活性化合物，并对其抗菌、抗炎和抗氧化潜力进行了评估。研究人员从龙牙草的叶片和根茎中分离出 59 个内生菌，其中 Fusarium fujikuroi PCLCUT2 和 Bacillus pacificus NCLALC2 具有显著的抗氧化和抗炎特性。PCLCUT2 显示出很强的抗氧化潜力（IC50 1.33 mg/mL），并含有(-)-表儿茶素和姜黄素等化合物。太平洋芽孢杆菌 NCLALC2 具有很强的消炎和抗菌潜力（MIC 200 µg/L）。NCLALC2 含有 12 种潜在的生物活性化合物，包括 Calicoferol D、萜品烯和α-黄柏烯。由于存在宿主特异性化合物，这两种内生菌有望成为具有成本效益的生物活性代谢物药用来源。

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The Microbe

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